{"doi":"10.1210/clinem/dgac313","title":"Sleep Fragmentation and Estradiol Suppression Decrease Fat Oxidation in Premenopausal Women","abstract":"CONTEXT: Body fat gain associated with menopause has been attributed to estradiol (E2) withdrawal. Hypoestrogenism is unlikely to be the only contributing factor, however. OBJECTIVE: Given the links between sleep and metabolic health, we examined the effects of an experimental menopausal model of sleep fragmentation on energy metabolism. METHODS: Twenty premenopausal women (age 21-45 years) underwent a 5-night inpatient study during the mid-to-late follicular phase (estrogenized; n = 20) and the same protocol was repeated in a subset of the participants (n = 9) following leuprolide-induced E2 suppression (hypo-estrogenized). During each 5-night study, there were 2 nights of unfragmented sleep followed by 3 nights of fragmented sleep. Indirect calorimetry was used to assess fasted resting energy expenditure (REE) and substrate oxidation. RESULTS: Sleep fragmentation in the estrogenized state increased the respiratory exchange ratio (RER) and carbohydrate oxidation while decreasing fat oxidation (all P < 0.01). Similarly, in the hypo-estrogenized state without sleep fragmentation, RER and carbohydrate oxidation increased and fat oxidation decreased (all P < 0.01); addition of sleep fragmentation to the hypo-estrogenized state did not produce further effects beyond that observed for either intervention alone (P < 0.05). There were no effects of either sleep fragmentation or E2 state on REE. CONCLUSION: Sleep fragmentation and hypoestrogenism each independently alter fasting substrate oxidation in a manner that may contribute to body fat gain. These findings are important for understanding mechanisms underlying propensity to body fat gain in women across the menopause transition.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2022,"id":260932,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9372,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":915766,"name":"Jamie Coborn","orcid":null,"position":1,"is_corresponding":false},{"id":311930,"name":"Aviva Cohn","orcid":"0000-0001-8976-6544","position":2,"is_corresponding":false},{"id":915077,"name":"Margo Nathan","orcid":"0000-0003-4347-4874","position":3,"is_corresponding":false},{"id":249994,"name":"Frank A. J. L. Scheer","orcid":"0000-0002-2014-7582","position":4,"is_corresponding":false},{"id":198944,"name":"Elizabeth B. Klerman","orcid":"0000-0002-7402-3171","position":5,"is_corresponding":false},{"id":160512,"name":"Ursula B Kaiser","orcid":"0000-0002-8237-0704","position":6,"is_corresponding":false},{"id":736766,"name":"Jessica Harder","orcid":null,"position":7,"is_corresponding":false},{"id":915767,"name":"Mathena Abramson","orcid":null,"position":8,"is_corresponding":false},{"id":915768,"name":"Elkhansaa Elguenaoui","orcid":null,"position":9,"is_corresponding":false},{"id":915769,"name":"Julia Russell","orcid":null,"position":10,"is_corresponding":false},{"id":736767,"name":"Aleta Wiley","orcid":null,"position":11,"is_corresponding":false},{"id":342319,"name":"Shadab A. Rahman","orcid":"0000-0002-8729-0500","position":12,"is_corresponding":false},{"id":284571,"name":"Hadine Joffe","orcid":"0000-0002-7035-8249","position":13,"is_corresponding":false},{"id":506817,"name":"Leilah K Grant","orcid":"0000-0002-6165-7044","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T00:26:12.158801Z","pmid":"35569055","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}