{"doi":"10.1210/clinem/dgac056","title":"Population-based Assessment of Cardiometabolic-related Diagnoses in Youth With Klinefelter Syndrome: A PEDSnet Study","abstract":"CONTEXT: Diabetes and cardiovascular diseases are common among men with Klinefelter syndrome (KS) and contribute to high morbidity and mortality. OBJECTIVE: To determine if cardiometabolic-related diagnoses are more prevalent among youth with KS than matched controls in a large population-based cohort. METHODS: Secondary data analysis of electronic health records from 6 pediatric institutions in the United States (PEDSnet). Patients included all youth with KS in the database (n = 1080) and 4497 youth without KS matched for sex, age (mean 13 years at last encounter), year of birth, race, ethnicity, insurance, site, and duration of care (mean 7 years). The main outcome measures were prevalence of 5 cardiometabolic-related outcomes: overweight/obesity, dyslipidemia, dysglycemia, hypertension, and liver dysfunction. RESULTS: The odds of overweight/obesity (OR 1.6; 95% CI 1.4-1.8), dyslipidemia (3.0; 2.2-3.9), and liver dysfunction (2.0; 1.6-2.5) were all higher in KS than in controls. Adjusting for covariates (obesity, testosterone treatment, and antipsychotic use) attenuated the effect of KS on these outcomes; however, boys with KS still had 45% greater odds of overweight/obesity (95% CI 1.2-1.7) and 70% greater odds of liver dysfunction (95% CI 1.3-2.2) than controls, and both dyslipidemia (1.6; 1.1-2.4) and dysglycemia (1.8; 1.1-3.2) were higher in KS but of borderline statistical significance when accounting for multiple comparisons. The odds of hypertension were not different between groups. CONCLUSION: This large, population-based cohort of youth with KS had a higher odds of most cardiometabolic-related diagnoses than matched controls.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2022,"id":245761,"datarank":0.6114361816252196,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.17788041794079493,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.17788041794079493,"corpus_percentile":67.78061421830277,"corpus_rank":4166,"citation_count":17,"citer_count":14,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7116,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":497788,"name":"Natalie Nokoff","orcid":"0000-0002-9190-3947","position":1,"is_corresponding":false},{"id":675065,"name":"Anna Furniss","orcid":"0000-0001-5498-607X","position":2,"is_corresponding":false},{"id":254435,"name":"Laura Pyle","orcid":"0000-0001-5577-8221","position":3,"is_corresponding":false},{"id":880925,"name":"Anna Valentine","orcid":"0000-0002-5098-789X","position":4,"is_corresponding":false},{"id":880926,"name":"Patricia Y. Fechner","orcid":"0000-0002-1243-8304","position":5,"is_corresponding":false},{"id":880927,"name":"Chijioke Ikomi","orcid":"0000-0002-0630-2355","position":6,"is_corresponding":false},{"id":675961,"name":"Brianna Magnusen","orcid":null,"position":7,"is_corresponding":false},{"id":385066,"name":"Leena Nahata","orcid":"0000-0003-3899-2642","position":8,"is_corresponding":false},{"id":670473,"name":"Maria G. Vogiatzi","orcid":"0000-0001-9523-0084","position":9,"is_corresponding":false},{"id":462981,"name":"Amanda F. Dempsey","orcid":"0000-0001-7085-6259","position":10,"is_corresponding":false},{"id":278326,"name":"Shanlee Davis","orcid":"0000-0002-0304-9550","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T00:23:39.284121Z","pmid":"35106546","pmcid":"PMC9272432","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}