{"doi":"10.1210/clinem/dgab883","title":"Prebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial","abstract":"CONTEXT: The adverse skeletal effects of Roux-en-Y gastric bypass (RYGB) are partly caused by intestinal calcium absorption decline. Prebiotics, such as soluble corn fiber (SCF), augment colonic calcium absorption in healthy individuals. OBJECTIVE: We tested the effects of SCF on fractional calcium absorption (FCA), biochemical parameters, and the fecal microbiome in a post-RYGB population. METHODS: Randomized, double-blind, placebo-controlled trial of 20 postmenopausal women with history of RYGB a mean 5 years prior; a 2-month course of 20 g/day SCF or maltodextrin placebo was taken orally. The main outcome measure was between-group difference in absolute change in FCA (primary outcome) and was measured with a gold standard dual stable isotope method. Other measures included tolerability, adherence, serum calciotropic hormones and bone turnover markers, and fecal microbial composition via 16S rRNA gene sequencing. RESULTS: Mean FCA ± SD at baseline was low at 5.5 ± 5.1%. Comparing SCF to placebo, there was no between-group difference in mean (95% CI) change in FCA (+3.4 [-6.7, +13.6]%), nor in calciotropic hormones or bone turnover markers. The SCF group had a wider variation in FCA change than placebo (SD 13.4% vs 7.0%). Those with greater change in microbial composition following SCF treatment had greater increase in FCA (r2 = 0.72, P = 0.05). SCF adherence was high, and gastrointestinal symptoms were similar between groups. CONCLUSION: No between-group differences were observed in changes in FCA or calciotropic hormones, but wide CIs suggest a variable impact of SCF that may be due to the degree of gut microbiome alteration. Daily SCF consumption was well tolerated. Larger and longer-term studies are warranted.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2021,"id":179960,"datarank":0.6499097440527983,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.20824389717783226,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.20824389717783226,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":16,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9603,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03272542"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245685,"name":"Sisi Cao","orcid":"0000-0002-7413-295X","position":1,"is_corresponding":false},{"id":78487,"name":"Connie M. Weaver","orcid":"0000-0002-5450-9609","position":2,"is_corresponding":false},{"id":728339,"name":"Nicole J King","orcid":"0009-0008-0470-2380","position":3,"is_corresponding":false},{"id":109417,"name":"Sheena Patel","orcid":null,"position":4,"is_corresponding":false},{"id":729130,"name":"Hillary Kingman","orcid":null,"position":5,"is_corresponding":false},{"id":449340,"name":"Deborah E. Sellmeyer","orcid":"0000-0003-4571-1386","position":6,"is_corresponding":false},{"id":424483,"name":"Kathryn McCauley","orcid":"0000-0002-8760-0599","position":7,"is_corresponding":false},{"id":660611,"name":"Danny Li","orcid":"0000-0002-4453-9126","position":8,"is_corresponding":false},{"id":233436,"name":"Susan V. Lynch","orcid":"0000-0001-5695-7336","position":9,"is_corresponding":false},{"id":728340,"name":"Tiffany Y. Kim","orcid":"0000-0002-6889-9636","position":10,"is_corresponding":false},{"id":19284,"name":"Dennis M. Black","orcid":"0000-0001-5318-7575","position":11,"is_corresponding":false},{"id":373849,"name":"Martin M. Shafer","orcid":"0000-0002-0810-298X","position":12,"is_corresponding":false},{"id":728341,"name":"Mustafa Özçam","orcid":"0000-0003-1834-6942","position":13,"is_corresponding":false},{"id":424482,"name":"Din L. Lin","orcid":"0000-0001-7101-9620","position":14,"is_corresponding":false},{"id":546392,"name":"Stanley J. Rogers","orcid":null,"position":15,"is_corresponding":false},{"id":728342,"name":"Lygia Stewart","orcid":"0000-0003-2778-7950","position":16,"is_corresponding":false},{"id":545831,"name":"Jonathan Carter","orcid":"0000-0001-9006-7636","position":17,"is_corresponding":false},{"id":725143,"name":"Andrew M. Posselt","orcid":null,"position":18,"is_corresponding":false},{"id":338729,"name":"Anne L. Schafer","orcid":"0000-0002-4750-9125","position":19,"is_corresponding":false},{"id":728338,"name":"Karin C Wu","orcid":"0000-0001-8615-2897","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-18T23:47:53.089578Z","pmid":"34888663","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}