{"doi":"10.1210/clinem/dgab878","title":"Letter to the Editor From Malozowski: “Weekly Lonapegsomatropin in Treatment-naïve Children with Growth Hormone Deficiency: the Phase 3 heiGHt Trial”","abstract":"The Thornton et al. study (1) formally explored whether a long-acting human growth hormone (LAGH) would increase treatment adherence when compared with daily growth hormone (GH) dosing. Adherence was defined as the ratio of total number of administered to planned doses assessed by drug accountability records and patient diaries. The study was properly designed and successful in showing equivalence in promoting statural growth, replicating prior studies with other LAGHs (2), but surprisingly failed to show differences in adherence—99.6% for the daily injections and 98.6% for the LAGH—thereby scientifically rejecting the hypothesis of increased LAGH compliance and disputing this strong held belief of better adherence. The authors, while endorsing the efficacy outcome, however, simultaneously disregarded and rejected their own adherence findings stating [sic] “…high levels of adherence are anticipated in a controlled clinical trial and may not be reflective of a real-world setting. The decrease in the number of injections is expected to reduce the overall treatment burden and may improve adherence in a real-world setting, potentially translating to improved overall outcomes.”","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2021,"id":222195,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":460706,"name":"Saúl Malozowski","orcid":"0000-0003-2029-3050","position":0,"is_corresponding":true}],"reference_count":6,"raw_metadata":null,"created_at":"2026-07-18T23:54:03.549854Z","pmid":"34918085","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}