{"doi":"10.1210/clinem/dgab508","title":"Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults","abstract":"CONTEXT: Studies in rodents and humans suggest that high-fructose corn syrup (HFCS)-sweetened diets promote greater metabolic dysfunction than sucrose-sweetened diets. OBJECTIVE: To compare the effects of consuming sucrose-sweetened beverage (SB), HFCS-SB, or a control beverage sweetened with aspartame on metabolic outcomes in humans. METHODS: A parallel, double-blinded, NIH-funded study. Experimental procedures were conducted during 3.5 days of inpatient residence with controlled feeding at a research clinic before (baseline) and after a 12-day outpatient intervention period. Seventy-five adults (18-40 years) were assigned to beverage groups matched for sex, body mass index (18-35 kg/m2), and fasting triglyceride, lipoprotein and insulin concentrations. The intervention was 3 servings/day of sucrose- or HFCS-SB providing 25% of energy requirement or aspartame-SB, consumed for 16 days. Main outcome measures were %hepatic lipid, Matsuda insulin sensitivity index (ISI), and Predicted M ISI. RESULTS: Sucrose-SB increased %hepatic lipid (absolute change: 0.6 ± 0.2%) compared with aspartame-SB (-0.2 ± 0.2%, P < 0.05) and compared with baseline (P < 0.001). HFCS-SB increased %hepatic lipid compared with baseline (0.4 ± 0.2%, P < 0.05). Compared with aspartame-SB, Matsuda ISI decreased after consumption of HFCS- (P < 0.01) and sucrose-SB (P < 0.01), and Predicted M ISI decreased after consumption of HFCS-SB (P < 0.05). Sucrose- and HFCS-SB increased plasma concentrations of lipids, lipoproteins, and uric acid compared with aspartame-SB. No outcomes were differentially affected by sucrose- compared with HFCS-SB. Beverage group effects remained significant when analyses were adjusted for changes in body weight. CONCLUSION: Consumption of both sucrose- and HFCS-SB induced detrimental changes in hepatic lipid, insulin sensitivity, and circulating lipids, lipoproteins and uric acid in 2 weeks.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2021,"id":167404,"datarank":1.127260733754086,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.602784599534114,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.602784599534114,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":27,"citers_with_citation_signal":24,"citers_with_endowment":24,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9166,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01103921"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":474605,"name":"Bettina Hieronimus","orcid":"0000-0001-7494-4707","position":1,"is_corresponding":false},{"id":378840,"name":"Valentina Medici","orcid":"0000-0001-5438-284X","position":2,"is_corresponding":false},{"id":474606,"name":"Vivien Lee","orcid":"0000-0002-8615-198X","position":3,"is_corresponding":false},{"id":475895,"name":"Marinelle V. Nuñez","orcid":null,"position":4,"is_corresponding":false},{"id":438056,"name":"Andrew A. Bremer","orcid":"0000-0002-7372-8372","position":5,"is_corresponding":false},{"id":695740,"name":"Chad L. Cox","orcid":null,"position":6,"is_corresponding":false},{"id":694779,"name":"Candice A. Price","orcid":"0000-0003-0661-0136","position":7,"is_corresponding":false},{"id":694780,"name":"Yanet Benyam","orcid":"0000-0001-8062-497X","position":8,"is_corresponding":false},{"id":477792,"name":"Abhijit J. Chaudhari","orcid":"0000-0002-4211-1900","position":9,"is_corresponding":false},{"id":336773,"name":"Yasser G. Abdelhafez","orcid":"0000-0002-1989-3094","position":10,"is_corresponding":false},{"id":437743,"name":"John P. McGahan","orcid":"0000-0003-0933-8772","position":11,"is_corresponding":false},{"id":254147,"name":"Michael I. Goran","orcid":"0000-0002-6897-6961","position":12,"is_corresponding":false},{"id":232504,"name":"Claude B. Sirlin","orcid":"0000-0002-6639-9072","position":13,"is_corresponding":false},{"id":694781,"name":"Giovanni Pacini","orcid":"0000-0002-4000-2583","position":14,"is_corresponding":false},{"id":481209,"name":"Andrea Tura","orcid":"0000-0003-3466-5900","position":15,"is_corresponding":false},{"id":474608,"name":"Nancy L. Keim","orcid":"0000-0002-6601-7572","position":16,"is_corresponding":false},{"id":430378,"name":"Peter J. Havel","orcid":"0000-0003-3652-8301","position":17,"is_corresponding":false},{"id":438053,"name":"Kimber L. Stanhope","orcid":"0000-0002-2474-0914","position":18,"is_corresponding":false},{"id":474607,"name":"Desiree M. Sigala","orcid":"0000-0003-4738-6222","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-18T23:45:58.359801Z","pmid":"34265055","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}