{"doi":"10.1210/clinem/dgab468","title":"Cardiometabolic Outcomes and Mortality in Patients with Adrenal Adenomas in a Population-based Setting","abstract":"CONTEXT: While adrenal adenomas have been linked with cardiovascular morbidity in convenience samples of patients from specialized referral centers, large-scale population-based data are lacking. OBJECTIVE: To determine the prevalence and incidence of cardiometabolic disease and assess mortality in a population-based cohort of patients with adrenal adenomas. DESIGN: Population-based cohort study. SETTING: Olmsted County, Minnesota, USA. PATIENTS: Patients diagnosed with adrenal adenomas without overt hormone excess and age- and sex-matched referent subjects without adrenal adenomas. MAIN OUTCOME MEASURE: Prevalence, incidence of cardiometabolic outcomes, mortality. RESULTS: (Adrenal adenomas were diagnosed in 1004 patients (58% women, median age 63 years) from 1/01/1995 to 12/31/2017. At baseline, patients with adrenal adenomas were more likely to have hypertension [adjusted odds ratio (aOR) 1.96, 95% CI 1.58-2.44], dysglycemia (aOR 1.63, 95% CI 1.33-2.00), peripheral vascular disease (aOR 1.59, 95% CI 1.32-2.06), heart failure (aOR 1.64, 95% CI 1.15-2.33), and myocardial infarction (aOR 1.50, 95% CI 1.02-2.22) compared to referent subjects. During median follow-up of 6.8 years, patients with adrenal adenomas were more likely than referent subjects to develop de novo chronic kidney disease [adjusted hazard ratio (aHR) 1.46, 95% CI 1.14-1.86], cardiac arrhythmia (aHR 1.31, 95% CI 1.08-1.58), peripheral vascular disease (aHR 1.28, 95% CI 1.05-1.55), cardiovascular events (aHR 1.33, 95% CI 1.01-1.73), and venous thromboembolic events (aHR 2.15, 95% CI 1.48-3.13). Adjusted mortality was similar between the 2 groups. CONCLUSION: Adrenal adenomas are associated with an increased prevalence and incidence of adverse cardiometabolic outcomes in a population-based cohort.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2021,"id":164619,"datarank":1.0436751372719715,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.4941408903525244,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.4941408903525244,"corpus_percentile":80.59101106211804,"corpus_rank":2510,"citation_count":38,"citer_count":25,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6001,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":337140,"name":"Dingfeng Li","orcid":"0000-0001-5795-0419","position":1,"is_corresponding":false},{"id":311933,"name":"Ravinder Jeet Kaur","orcid":"0000-0001-6445-2776","position":2,"is_corresponding":false},{"id":311948,"name":"Andreas Ebbehøj","orcid":"0000-0001-7104-7824","position":3,"is_corresponding":false},{"id":467964,"name":"Sumitabh Singh","orcid":"0000-0001-6203-6955","position":4,"is_corresponding":false},{"id":97274,"name":"Elizabeth J. Atkinson","orcid":"0000-0002-1191-3775","position":5,"is_corresponding":false},{"id":300279,"name":"Sara J. Achenbach","orcid":null,"position":6,"is_corresponding":false},{"id":239619,"name":"William F. Young","orcid":"0000-0001-5481-4884","position":7,"is_corresponding":false},{"id":239621,"name":"Wiebke Arlt","orcid":"0000-0001-5106-9719","position":8,"is_corresponding":false},{"id":17537,"name":"Walter A. Rocca","orcid":"0000-0002-1832-7664","position":9,"is_corresponding":false},{"id":239586,"name":"Irina Bancos","orcid":"0000-0001-9332-2524","position":10,"is_corresponding":false},{"id":686625,"name":"Catherine D Zhang","orcid":"0000-0003-2784-2673","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T23:45:32.226038Z","pmid":"34185830","pmcid":"PMC8530703","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}