{"doi":"10.1210/clinem/dgab187","title":"Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Body Composition From Mid-Childhood to Early Adolescence","abstract":"CONTEXT: Per- and polyfluoroalkyl substances (PFAS) may alter body composition by lowering anabolic hormones and increasing inflammation, but data are limited, particularly in adolescence when body composition is rapidly changing. OBJECTIVE: To evaluate associations of PFAS plasma concentrations in childhood with change in body composition through early adolescence. METHODS: A total of 537 children in the Boston-area Project Viva cohort participated in this study. We used multivariable linear regression and Bayesian kernel machine regression (BKMR) to examine associations of plasma concentrations of 6 PFAS, quantified by mass spectrometry, in mid-childhood (mean age, 7.9 years; 2007-2010) with change in body composition measured by dual-energy x-ray absorptiometry from mid-childhood to early adolescence (mean age, 13.1 years). RESULTS: In single-PFAS linear regression models, children with higher concentrations of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorodecanoate (PFDA), and perfluorohexane sulfonate (PFHxS) had less accrual of lean mass (eg, -0.33 [95% CI: -0.52, -0.13] kg/m2 per doubling of PFOA). Children with higher PFOS and PFHxS had less accrual of total and truncal fat mass (eg, -0.32 [95% CI: -0.54, -0.11] kg/m2 total fat mass per doubling of PFOS), particularly subcutaneous fat mass (eg, -17.26 [95% CI -32.25, -2.27] g/m2 per doubling of PFOS). Children with higher PFDA and perfluorononanoate (PFNA) had greater accrual of visceral fat mass (eg, 0.44 [95% CI: 0.13, 0.75] g/m2 per doubling of PFDA). Results from BKMR mixture models were consistent with linear regression analyses. CONCLUSION: Early life exposure to some but not all PFAS may be associated with adverse changes in body composition.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2021,"id":158331,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8078,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":254530,"name":"Sheryl L. Rifas‐Shiman","orcid":"0000-0003-0033-920X","position":1,"is_corresponding":false},{"id":383336,"name":"Shravanthi M. Seshasayee","orcid":"0000-0002-1692-7121","position":2,"is_corresponding":false},{"id":254532,"name":"Sharon K. Sagiv","orcid":"0000-0003-2245-1905","position":3,"is_corresponding":false},{"id":241824,"name":"Antonia M. Calafat","orcid":"0000-0002-9796-7482","position":4,"is_corresponding":false},{"id":71916,"name":"Diane R. Gold","orcid":"0000-0001-8789-418X","position":5,"is_corresponding":false},{"id":94039,"name":"Brent A. Coull","orcid":"0000-0002-1808-4156","position":6,"is_corresponding":false},{"id":292704,"name":"Clifford J. Rosen","orcid":"0000-0003-3436-8199","position":7,"is_corresponding":false},{"id":239883,"name":"Emily Oken","orcid":"0000-0003-2513-3339","position":8,"is_corresponding":false},{"id":254531,"name":"Abby F. Fleisch","orcid":"0000-0002-2789-6412","position":9,"is_corresponding":false},{"id":666894,"name":"Jaclyn A. Janis","orcid":"0000-0002-8802-5629","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T23:44:26.210708Z","pmid":"33740056","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}