{"doi":"10.1210/clinem/dgaa985","title":"Preoperative BMI Predicts Postoperative Weight Gain in Adult-onset Craniopharyngioma","abstract":"CONTEXT: Craniopharyngiomas, while benign, have the highest morbidity of all nonmalignant sellar tumors. Studies on weight and metabolic outcomes in adult-onset craniopharyngioma (AOCP) remain sparse. OBJECTIVE: To examine postsurgical weight and metabolic outcomes in AOCP and to identify any clinical predictors of weight gain. METHODS: Retrospective chart review of patients with AOCP who underwent surgery between January 2014 and May 2019 in a single pituitary center. The study included 45 patients with AOCP with a minimum follow-up of 3 months. Median follow-up time was 26 months (interquartile range [IQR] 10-44). Main outcome measures were the changes in weight/body mass index (BMI), metabolic comorbidities, and pituitary deficiencies between preoperative and last follow-up. RESULTS: Both weight and BMI were higher at last follow-up, with a mean increase of 3.4 kg for weight (P = .015) and 1.15 kg/m2 for BMI (P = .0095). Median % weight change was 2.7% (IQR -1.1%, 8.8%). Obesity rate increased from 37.8% at baseline to 55.6% at last follow-up. One-third of patients had ~15% median weight gain. The prevalence of metabolic comorbidities at last follow-up was not different from baseline. Pituitary deficiencies increased postoperatively, with 58% of patients having ≥3 hormonal deficiencies. Preoperative BMI was inversely associated with postoperative weight gain, which remained significant after adjusting for age, sex, race, tumor, and treatment characteristics. Patients with ≥3 hormonal deficiencies at last follow-up also had higher postoperative weight gain. CONCLUSION: In this AOCP cohort, those with a lower BMI at the preoperative visit had higher postoperative weight gain. Our finding may help physicians better counsel patients and provide anticipatory guidance on postoperative expectations and management.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2021,"id":176012,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.935,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":717917,"name":"Leen Wehbeh","orcid":"0000-0001-6045-0706","position":1,"is_corresponding":false},{"id":284949,"name":"Debraj Mukherjee","orcid":"0000-0002-5403-8237","position":2,"is_corresponding":false},{"id":664786,"name":"Amir H. Hamrahian","orcid":"0000-0001-8832-9385","position":3,"is_corresponding":false},{"id":288108,"name":"Fausto J. Rodríguez","orcid":"0000-0001-8662-1219","position":4,"is_corresponding":false},{"id":717918,"name":"Sachin K. Gujar","orcid":"0000-0003-3343-5687","position":5,"is_corresponding":false},{"id":270638,"name":"Adham M. Khalafallah","orcid":"0000-0002-3249-9657","position":6,"is_corresponding":false},{"id":717919,"name":"Camille Hage","orcid":"0000-0002-6652-0725","position":7,"is_corresponding":false},{"id":108424,"name":"Patrizio Caturegli","orcid":"0000-0001-6768-6308","position":8,"is_corresponding":false},{"id":459882,"name":"Gary L. Gallia","orcid":"0000-0001-6438-7329","position":9,"is_corresponding":false},{"id":282974,"name":"Rexford S. Ahima","orcid":"0000-0002-3479-1942","position":10,"is_corresponding":false},{"id":367541,"name":"Nisa M. Maruthur","orcid":"0000-0002-5799-104X","position":11,"is_corresponding":false},{"id":311871,"name":"Roberto Salvatori","orcid":"0000-0001-6495-2244","position":12,"is_corresponding":false},{"id":266234,"name":"Daisy Duan","orcid":"0000-0002-4392-3206","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-18T23:47:19.591542Z","pmid":"33417676","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}