{"doi":"10.1210/clinem/dgaa808","title":"Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg)","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Context</jats:title>\n                  <jats:p>Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve gastrectomy (SG) have different effects on bone health.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Objective</jats:title>\n                  <jats:p>To compare changes in bone mineral density and markers of bone turnover 1 year after SG and RYGB.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Setting, Patients, and Interventions</jats:title>\n                  <jats:p>Randomized, triple-blind, single-center trial at a tertiary care center in Norway. The primary outcome was diabetes remission. Patients with severe obesity and type 2 diabetes were randomized and allocated (1:1) to SG or RYGB.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures</jats:title>\n                  <jats:p>Changes in areal bone mineral density (aBMD) and bone turnover markers.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Femoral neck, total hip, and lumbar spine aBMD, but not total body aBMD, decreased significantly more after RYGB (n = 44) than after SG (n = 48) (mean [95% confidence interval] between group differences -2.8% [-4.7 to -0.8], -3.0% [-5.0 to -0.9], -4.2% [-6.4 to -2.1], and -0.5% [-1.6 to 0.6], respectively). The increase in procollagen type 1 N-terminal propeptide (P1NP) and C-telopeptide of type I collagen (CTX-1) were approximately 100% higher after RYGB than after SG (between group difference at 1 year, both P &amp;lt; 0.001). The changes in femoral neck, total hip, and lumbar spine aBMDs and the changes in P1NP and CTX-1 were independently associated with the surgical procedure (all P &amp;lt; 0.05) and not weight change.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Roux-en-Y gastric bypass was associated with a greater reduction in aBMD and a greater increase in bone turnover markers compared with SG. This finding could suggest greater skeletal fragility after RYGB.</jats:p>\n               </jats:sec>","journal":"The Journal of Clinical Endocrinology &amp; Metabolism","year":2021,"id":613083,"datarank":0.6141516843333151,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":0.0,"self_endowment_contribution":0.6141516843333151,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1579172,"name":"Thor Olav Widerøe Hillestad","orcid":null,"position":1,"is_corresponding":false},{"id":1579173,"name":"Erling Halvorsen","orcid":null,"position":2,"is_corresponding":false},{"id":1579174,"name":"Farhat Fatima","orcid":null,"position":3,"is_corresponding":false},{"id":1579175,"name":"Line Kristin Johnson","orcid":null,"position":4,"is_corresponding":false},{"id":1579176,"name":"Morten Lindberg","orcid":"0000-0002-5568-7810","position":5,"is_corresponding":false},{"id":1579177,"name":"Marius Svanevik","orcid":null,"position":6,"is_corresponding":false},{"id":1579178,"name":"Rune Sandbu","orcid":null,"position":7,"is_corresponding":false},{"id":1579179,"name":"Jøran Hjelmesæth","orcid":null,"position":8,"is_corresponding":false},{"id":1579171,"name":"Dag Hofsø","orcid":"0000-0002-8877-1162","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg)","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Context</jats:title>\n                  <jats:p>Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve gastrectomy (SG) have different effects on bone health.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Objective</jats:title>\n                  <jats:p>To compare changes in bone mineral density and markers of bone turnover 1 year after SG and RYGB.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Setting, Patients, and Interventions</jats:title>\n                  <jats:p>Randomized, triple-blind, single-center trial at a tertiary care center in Norway. The primary outcome was diabetes remission. Patients with severe obesity and type 2 diabetes were randomized and allocated (1:1) to SG or RYGB.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures</jats:title>\n                  <jats:p>Changes in areal bone mineral density (aBMD) and bone turnover markers.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Femoral neck, total hip, and lumbar spine aBMD, but not total body aBMD, decreased significantly more after RYGB (n = 44) than after SG (n = 48) (mean [95% confidence interval] between group differences -2.8% [-4.7 to -0.8], -3.0% [-5.0 to -0.9], -4.2% [-6.4 to -2.1], and -0.5% [-1.6 to 0.6], respectively). The increase in procollagen type 1 N-terminal propeptide (P1NP) and C-telopeptide of type I collagen (CTX-1) were approximately 100% higher after RYGB than after SG (between group difference at 1 year, both P &amp;lt; 0.001). The changes in femoral neck, total hip, and lumbar spine aBMDs and the changes in P1NP and CTX-1 were independently associated with the surgical procedure (all P &amp;lt; 0.05) and not weight change.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>Roux-en-Y gastric bypass was associated with a greater reduction in aBMD and a greater increase in bone turnover markers compared with SG. This finding could suggest greater skeletal fragility after RYGB.</jats:p>\n               </jats:sec>","is_dataset_classified":null,"base_score":4.0943445622221,"endowment":4.0943445622221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33150385","pmcid":"PMC7823313","openalex_id":"https://openalex.org/W3096731056","authors":[],"funders":[{"funder_name":"South-Eastern Norway Regional Health Authority","grant_id":"","title":null}],"total_grants":1,"fwci":5.9148,"citation_percentile":0.97216699,"influential_citations":0,"citation_trend":[{"year":2021,"count":7},{"year":2022,"count":14},{"year":2023,"count":8},{"year":2024,"count":17},{"year":2025,"count":9},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://academic.oup.com/jcem/article-pdf/106/2/501/41849740/dgaa808.pdf","host_type":"journal"},{"url":"https://academic.oup.com/jcem/article-pdf/106/2/501/41849740/dgaa808.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgaa808/35001888/dgaa808.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1210/clinem/dgaa808","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33150385","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC7823313","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7823313","host_type":"repository"},{"url":"http://hdl.handle.net/10852/82156","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7823313","host_type":"Europe_PMC"}],"fields_of_study":["Bariatric Surgery and Outcomes","Bone health and osteoporosis research","Parathyroid Disorders and Treatments"],"mesh_terms":["Diabetes Mellitus, Type 2","Female","Follow-Up Studies","Gastrectomy","Humans","Male","Middle Aged","Obesity, Morbid","Prognosis","Gastric Bypass","Bone Density","Bone Remodeling","Fractures, Bone"],"keywords":["Medicine","Bone mineral","Bone remodeling","Femoral neck","N-terminal telopeptide","Context (archaeology)","Sleeve gastrectomy","Surgery","Bone density","Gastric bypass surgery","Randomized controlled trial","Internal medicine","Gastroenterology","Weight loss","Obesity","Osteoporosis","Gastric bypass","Type 2 diabetes","Bone turnover","bone mineral density","Morbid Obesity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T06:32:51.345177Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}