{"doi":"10.1210/clinem/dgaa799","title":"Brown Fat–Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity","abstract":"CONTEXT: Little is known about the specific breastmilk components responsible for protective effects on infant obesity. Whether 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), an oxidized linoleic acid metabolite and activator of brown fat metabolism, is present in human milk, or linked to infant adiposity, is unknown. OBJECTIVE: To examine associations between concentrations of 12,13-diHOME in human milk and infant adiposity. DESIGN: Prospective cohort study from 2015 to 2019, following participants from birth to 6 months of age. SETTING: Academic medical centers. PARTICIPANTS: Volunteer sample of 58 exclusively breastfeeding mother-infant pairs; exclusion criteria included smoking, gestational diabetes, and health conditions with the potential to influence maternal or infant weight gain. MAIN OUTCOME MEASURES: Infant anthropometric measures including weight, length, body mass index (BMI), and body composition at birth and at 1, 3, and 6 months postpartum. RESULTS: We report for the first time that 12,13-diHOME is present in human milk. Higher milk 12,13-diHOME level was associated with increased weight-for-length Z-score at birth (β = 0.5742, P = 0.0008), lower infant fat mass at 1 month (P = 0.021), and reduced gain in BMI Z-score from 0 to 6 months (β = -0.3997, P = 0.025). We observed similar associations between infant adiposity and milk abundance of related oxidized linoleic acid metabolites 12,13-Epoxy-9(Z)-octadecenoic acid (12,13-epOME) and 9,10-Dihydroxy-12-octadecenoic acid (9,10-diHOME), and metabolites linked to thermogenesis including succinate and lyso-phosphatidylglycerol 18:0. Milk abundance of 12,13-diHOME was not associated with maternal BMI, but was positively associated with maternal height, milk glucose concentration, and was significantly increased after a bout of moderate exercise. CONCLUSIONS: We report novel associations between milk abundance of 12,13-diHOME and adiposity during infancy.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2020,"id":61247,"datarank":1.9568618546845613,"base_score":4.07753744390572,"endowment":4.07753744390572,"self_citation_contribution":0.611630616585858,"citation_network_contribution":1.3452312380987033,"self_endowment_contribution":0.611630616585858,"citer_contribution":1.3452312380987033,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":44,"citers_with_citation_signal":38,"citers_with_endowment":38,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02535637"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258919,"name":"Matthew D. Lynes","orcid":"0000-0003-0746-0854","position":1,"is_corresponding":false},{"id":60610,"name":"Yu‐Hua Tseng","orcid":"0000-0003-2053-9559","position":2,"is_corresponding":false},{"id":323525,"name":"Stephanie Pierce","orcid":"0000-0003-1328-8990","position":3,"is_corresponding":false},{"id":323526,"name":"Valerie Bussberg","orcid":"0009-0003-6830-3788","position":4,"is_corresponding":false},{"id":324756,"name":"Abena Darkwah","orcid":null,"position":5,"is_corresponding":false},{"id":258924,"name":"Vladimir Tolstikov","orcid":"0000-0002-0445-884X","position":6,"is_corresponding":false},{"id":258923,"name":"Niven R. Narain","orcid":"0000-0001-6769-1748","position":7,"is_corresponding":false},{"id":323527,"name":"Michael C. Rudolph","orcid":"0000-0002-6147-212X","position":8,"is_corresponding":false},{"id":258929,"name":"Michael A. Kiebish","orcid":"0000-0002-5678-0072","position":9,"is_corresponding":false},{"id":55292,"name":"Ellen W. Demerath","orcid":"0000-0002-4585-4064","position":10,"is_corresponding":false},{"id":71615,"name":"David A. Fields","orcid":"0000-0002-6845-1196","position":11,"is_corresponding":false},{"id":323528,"name":"Elvira Isganaitis","orcid":"0000-0003-3477-0305","position":12,"is_corresponding":false},{"id":324755,"name":"Danielle Wolfs","orcid":null,"position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T21:09:27.985420Z","pmid":"33135728","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}