{"doi":"10.1210/clinem/dgaa742","title":"Treatment of Gestational Diabetes Mellitus and Offspring Early Childhood Growth","abstract":"BACKGROUND: Gestational diabetes mellitus (GDM) is associated with fetal overgrowth, and certain treatments are associated with an increased risk of macrosomia. However, there are limited data about the long-term effect of GDM treatment on childhood growth. METHODS: Cohort study of 816 women with GDM and their offspring delivered between 2009 and 2012. Childhood height and weight through age 3 were collected from the medical record and z-scores and body mass index (BMI) were calculated. We assessed the association between GDM treatment and childhood growth using linear mixed modeling. RESULTS: Treatment was divided into medical nutritional therapy (MNT) (n = 293), glyburide (n = 421), and insulin (n = 102). At delivery, birthweight, z-score, and BMI were higher in the offspring of women treated with either glyburide or insulin compared to MNT. However, weight, z-score, and BMI were similar among all offspring at 6 months and 1, 2, and 3 years of age. After controlling for covariates, there were differences in the weight z-score (P = 0.01) over the 3-year period by treatment group, but no differences in weight (P = 0.06) or change in BMI (P = 0.28). Pairwise comparisons indicated that insulin was associated with more weight gain compared with MNT (0.69 kg; 95% CI, 0.10-1.28; P = 0.02) and glyburide was associated with a trend toward lower weight z-score compared with MNT (-0.24; 95% CI, -0.47 to 0.003; P = 0.05). CONCLUSION: Despite growth differences detected at birth, we observed no meaningful differences in childhood growth from 6 months to 3 years among treatment groups, including in the offspring of women with GDM treated with glyburide.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2020,"id":88525,"datarank":0.5593634591654933,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.1996791682457377,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.1996791682457377,"corpus_percentile":65.00348108609886,"corpus_rank":4525,"citation_count":10,"citer_count":8,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6186,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":375511,"name":"Jacqueline Atlass","orcid":null,"position":1,"is_corresponding":false},{"id":423729,"name":"Kaleab Z. Abebe","orcid":"0000-0002-3644-8419","position":2,"is_corresponding":false},{"id":450084,"name":"Diane Comer","orcid":null,"position":3,"is_corresponding":false},{"id":374584,"name":"Janet M. Catov","orcid":"0000-0002-9551-851X","position":4,"is_corresponding":false},{"id":331590,"name":"Steve N. Caritis","orcid":"0000-0002-2169-0712","position":5,"is_corresponding":false},{"id":448934,"name":"Silva Arslanian","orcid":"0000-0002-1528-9324","position":6,"is_corresponding":false},{"id":448935,"name":"Christina Scifres","orcid":"0000-0003-2992-7187","position":7,"is_corresponding":false},{"id":448933,"name":"Maisa Feghali","orcid":"0000-0001-6897-0845","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T22:01:22.387926Z","pmid":"33057663","pmcid":"PMC7993564","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}