{"doi":"10.1210/clinem/dgaa380","title":"Pediatric Reference Ranges for Ultradistal Radius Bone Density: Results from the Bone Mineral Density in Childhood Study","abstract":"CONTEXT: The ultradistal (UD) radius is rich in trabecular bone and is easily measured by dual energy X-ray absorptiometry (DXA). UD radius areal bone mineral density (aBMD) may help identify trabecular bone deficits, but reference data are needed for research and clinical interpretation of this measure. OBJECTIVE: We developed age-, sex-, and population ancestry-specific reference ranges for UD radius aBMD assessed by DXA and calculated Z-scores. We examined tracking of UD radius aBMD Z-scores over 6 years and determined associations between UD radius aBMD Z-scores and other bone measures by DXA and peripheral quantitative computed tomography. DESIGN: Multicenter longitudinal study. PARTICIPANTS: A total of 2014 (922 males, 22% African American) children ages 5 to 19 years at enrollment who participated in the Bone Mineral Density in Childhood Study. MAIN OUTCOME MEASURE: UD radius aBMD. RESULTS: UD radius aBMD increased nonlinearly with age (P < 0.001) and tended to be greater in males versus females (P = 0.054). Age-, sex-, and ancestry-specific UD radius aBMD reference curves were constructed. UD radius aBMD Z-scores positively associated with Z-scores at other skeletal sites (r = 0.54-0.64, all P < 0.001) and peripheral quantitative computed tomography measures of distal radius total volumetric BMD (r = 0.68, P < 0.001) and trabecular volumetric BMD (r = 0.70, P < 0.001), and was weakly associated with height Z-score (r = 0.09, P = 0.015). UD radius aBMD Z-scores tracked strongly over 6 years, regardless of pubertal stage (r = 0.66-0.69; all P < 0.05). CONCLUSION: UD radius aBMD Z-scores strongly associated with distal radius trabecular bone density, with marginal confounding by stature. These reference data may provide a valuable resource for bone health assessment in children.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2020,"id":99235,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5622,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":45180,"name":"Heidi J. Kalkwarf","orcid":"0000-0001-9030-8401","position":1,"is_corresponding":false},{"id":45181,"name":"Joan M. Lappe","orcid":"0000-0001-8274-2515","position":2,"is_corresponding":false},{"id":45185,"name":"Vicente Gilsanz","orcid":"0000-0001-5898-4901","position":3,"is_corresponding":false},{"id":45186,"name":"Sharon E. Oberfield","orcid":"0000-0001-9652-1107","position":4,"is_corresponding":false},{"id":34070,"name":"John Shepherd","orcid":"0000-0003-2280-2541","position":5,"is_corresponding":false},{"id":32955,"name":"Andrea Kelly","orcid":"0000-0003-1724-9868","position":6,"is_corresponding":false},{"id":298528,"name":"Karen K. Winer","orcid":"0000-0001-8261-5188","position":7,"is_corresponding":false},{"id":489596,"name":"Babette S Zemel","orcid":null,"position":8,"is_corresponding":false},{"id":45176,"name":"Joseph M. Kindler","orcid":"0000-0001-7613-4548","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T22:37:35.547042Z","pmid":"32561914","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}