{"doi":"10.1210/clinem/dgaa059","title":"AMH is Higher Across the Menstrual Cycle in Early Postmenarchal Girls than in Ovulatory Women","abstract":"CONTEXT: Adolescents have more small, growing follicles and larger ovaries than normal women and are prone to anovulatory cycles (ANOV). It is unknown if a higher antral follicle count (AFC) per se contributes to ANOV in early postmenarchal girls. OBJECTIVE: To determine the relationship between AMH (an AFC biomarker), other reproductive hormones, and ANOV in postmenarchal girls and to compare AMH in girls and regularly cycling adults. METHODS: A total of 23 girls (1.7 ± 0.2 years postmenarche) and 32 historic adult controls (≤34 years) underwent serial hormone measurements during 1 to 2 menstrual cycles. Girls also had pelvic ultrasounds. AMH was measured 5 times/subject using the Ansh ultrasensitive ELISA. RESULTS: Girls had higher AMH than women (5.2 ± 0.3 vs. 3.3 ± 0.4 ng/mL; P < 0.01) and girls with more ovulatory (OV) cycles tended to have lower AMH than those with ANOV (2 OV 4.5 ± 0.2, 1 OV 5.7 ± 1.1, 0 OV 6.8 ± 1.1 ng/mL; P = 0.1). In girls, AMH correlated with natural-log (ln) transformed LH (r = 0.5, P = 0.01), ln_androstenedione (r = 0.6, P = 0.003), ln_testosterone (r = 0.5, P = 0.02), and ovarian volume (r = 0.7, P < 0.01) but not with FSH, estradiol, P4, or body mass index. In women, AMH correlated with estradiol and P4 (both r = -0.4, P ≤ 0.03) but not with ln_LH or body mass index. CONCLUSIONS: In postmenarchal girls, AMH is higher than in ovulatory women and is associated with LH, androgens, and a propensity for anovulatory cycles. The cause of the transient increase in AMH and AFC during late puberty and the steps underlying the transition to a mature ovary deserve further study.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2020,"id":87278,"datarank":0.5895600528266367,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.2168240553584366,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.2168240553584366,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02486757"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":443878,"name":"Lauren Carlson","orcid":"0009-0005-9421-2120","position":1,"is_corresponding":false},{"id":89235,"name":"John A. McGrath","orcid":"0000-0002-9756-7892","position":2,"is_corresponding":false},{"id":444746,"name":"Tairmae Kangarloo","orcid":null,"position":3,"is_corresponding":false},{"id":55481,"name":"Judith Adams","orcid":"0000-0003-0378-2231","position":4,"is_corresponding":false},{"id":284568,"name":"Patrick M. Sluss","orcid":"0000-0003-2536-134X","position":5,"is_corresponding":false},{"id":384657,"name":"Geralyn Lambert‐Messerlian","orcid":"0000-0002-9440-3411","position":6,"is_corresponding":false},{"id":338018,"name":"Natalie D. Shaw","orcid":"0000-0002-0847-9170","position":7,"is_corresponding":false},{"id":338017,"name":"Madison Ortega","orcid":"0000-0001-9580-1393","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T21:59:31.247492Z","pmid":"32016427","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}