{"doi":"10.1210/clinem/dgaa006","title":"Bariatric Surgery vs Lifestyle Intervention for Diabetes Treatment: 5-Year Outcomes From a Randomized Trial","abstract":"CONTEXT: Questions remain about bariatric surgery for type 2 diabetes mellitus (T2DM) treatment. OBJECTIVE: Compare the remission of T2DM following surgical or nonsurgical treatments. DESIGN, SETTING, AND PARTICIPANTS: Randomized controlled trial at the University of Pittsburgh, in the United States. Five-year follow-up from February 2015 until June 2016. INTERVENTIONS: 61 participants with obesity and T2DM who were initially randomized to either bariatric surgical treatments (Roux-en-Y gastric bypass [RYGB] or laparoscopic adjustable gastric banding [LAGB]) or an intensive lifestyle weight loss intervention (LWLI) program for 1 year. Lower level lifestyle weight loss interventions (LLLIs) were then delivered for 4 years. MAIN OUTCOMES AND MEASURES: Diabetes remission assessed at 5 years. RESULTS: The mean age of the patients was 47 ± 6.6 years, 82% were women, and 21% African American. Mean hemoglobin A1c level 7.8% ± 1.9%, body mass index (BMI) 35.7 ± 3.1 kg/m2, and 26 participants (43%) had BMI < 35 kg/m2. Partial or complete T2DM remission was achieved by 30% (n = 6) of RYGB, 19% (n = 4) of LAGB, and no LWLI participants (P = .0208). At 5 years those in the RYGB group had the largest percentage of individuals (56%) not requiring any medications for T2DM compared with those in the LAGB (45%) and LWLI (0%) groups (P = .0065). Mean reductions in percent body weight at 5 years was the greatest after RYGB 25.2% ± 2.1%, followed by LAGB 12.7% ± 2.0% and lifestyle treatment 5.1% ± 2.5% (all pairwise P < .01). CONCLUSIONS: Surgical treatments are more effective than lifestyle intervention alone for T2DM treatment.","journal":"The Journal of Clinical Endocrinology & Metabolism","year":2020,"id":50849,"datarank":4.4592111296067545,"base_score":5.176149732573829,"endowment":5.176149732573829,"self_citation_contribution":0.7764224598860744,"citation_network_contribution":3.68278866972068,"self_endowment_contribution":0.7764224598860744,"citer_contribution":3.68278866972068,"corpus_percentile":null,"corpus_rank":null,"citation_count":176,"citer_count":100,"citers_with_citation_signal":100,"citers_with_endowment":100,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8273,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01047735"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":253142,"name":"James W. Gallagher","orcid":null,"position":1,"is_corresponding":false},{"id":251505,"name":"Rebecca H. Neiberg","orcid":"0000-0003-0719-6520","position":2,"is_corresponding":false},{"id":253143,"name":"Emily B Eagleton","orcid":null,"position":3,"is_corresponding":false},{"id":251506,"name":"James P. DeLany","orcid":"0000-0003-0366-3849","position":4,"is_corresponding":false},{"id":251507,"name":"Wei Lang","orcid":"0000-0002-8853-4458","position":5,"is_corresponding":false},{"id":251508,"name":"Suriya Punchai","orcid":"0000-0001-8154-0268","position":6,"is_corresponding":false},{"id":31467,"name":"William Gourash","orcid":"0000-0001-6824-0631","position":7,"is_corresponding":false},{"id":235351,"name":"John M. Jakicic","orcid":"0000-0001-6800-9368","position":8,"is_corresponding":false},{"id":31468,"name":"Anita P. Courcoulas","orcid":"0000-0002-4973-7869","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T20:39:29.006085Z","pmid":"31917447","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}