{"doi":"10.1201/9781003247432-15","title":"Helper-Dependent Adenoviral Vectors","abstract":"Significant improvement in the safety and efficacy of Ad-based vectors came with the development of helper-dependent adenoviral (HDAd) vectors (also referred to as gutless, gutted, mini, fully deleted, high-capacity, pseudo) that are deleted of all viral coding sequences. HDAd vectors retain the advantages of First-generation Ad including high efficiency in vivo transduction and high-level transgene expression. HDAd vectors are particularly attractive vectors for liver-directed gene therapy because of their ability to efficiently transduce hepatocytes following intravenous injection. HDAd vectors possess many characteristics that make them attractive vectors for gene therapy of a wide variety of genetic and acquired diseases. However, acute toxicity provoked by the viral capsid currently hinders the clinical application of this otherwise promising technology. Clearly, studies to elucidate the mechanism(s) of Ad-mediated activation of the innate inflammatory response are needed.","journal":null,"year":2022,"id":308868,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.947,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":276571,"name":"Philip Ng","orcid":null,"position":0,"is_corresponding":true}],"reference_count":152,"raw_metadata":null,"created_at":"2026-07-19T00:33:07.132912Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}