{"doi":"10.1201/9781003056713-21","title":"Exploration of the Nanomedicine-Design Space with High-throughput Screening and Machine Learning*","abstract":"Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant high-throughput synthesis and analysis methods.Here, we report a methodology for determining structure-activity relationships and design rules for spherical nucleic acids (SNAs) functioning as cancer-vaccine candidates.First, we identified ~1,000 candidate SNAs on the basis of reasonable ranges for 11 design parameters that can be systematically and independently varied to optimize SNA performance.Second, we developed a high-throughput method for making SNAs at the picomolar scale in a 384-well","journal":"Spherical Nucleic Acids","year":2020,"id":111451,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9434,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":488517,"name":"Eric J. Berns","orcid":"0000-0002-2203-0847","position":1,"is_corresponding":false},{"id":528872,"name":"Albert Xue","orcid":"0000-0001-8561-9416","position":2,"is_corresponding":false},{"id":478839,"name":"Andrew Lee","orcid":"0000-0002-7665-1999","position":3,"is_corresponding":false},{"id":287700,"name":"Neda Bagheri","orcid":"0000-0003-0146-4627","position":4,"is_corresponding":false},{"id":268924,"name":"Milan Mrksich","orcid":"0000-0002-4964-796X","position":5,"is_corresponding":false},{"id":79412,"name":"Chad A. Mirkin","orcid":"0000-0002-6634-7627","position":6,"is_corresponding":false},{"id":488482,"name":"Gokay Yamankurt","orcid":"0000-0003-2017-9848","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:05.597252Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}