{"doi":"10.1200/po.20.00121","title":"Turnaround Time of Plasma Next-Generation Sequencing in Thoracic Oncology Patients: A Quality Improvement Analysis","abstract":"PURPOSE: Genomic analysis of plasma cell-free DNA has become a widespread tool for advanced non-small-cell lung cancer care. Whereas accuracy has been reported on widely, its usefulness is also tied tightly to its turnaround time (TAT), which is not well studied. METHODS: We studied the TAT of commercial plasma next-generation sequencing (NGS; Guardant360) for 533 results from 461 patients at our center between August 2016 and October 2019. The study received institutional review board approval as a quality improvement study; therefore, the results of the test and clinical setting were not analyzed. RESULTS: TAT from blood draw to result (median of 9 days) was slightly longer than the TAT from laboratory receipt to result, a median of 7 days. Testing volume at our center increased three-fold over the time of the study. During this period, clinical TAT decreased from an initial median of 12 days to a median of 8 days in 2018, but more recently the median increased slightly to 9 days. During the most recent 12 months, 231 (95%) of 247 cases resulted within 14 days from blood draw, with delayed results usually because of billing, whereas 44 cases (18%) resulted within 7 days of blood draw. Studying 92 cases drawn in the most recent 3-month period, the median time of result receipt was 4:01 pm Eastern Time/1:01 pm Pacific Time; 39 results (43%) were returned after 5:00 pm Eastern Time. CONCLUSION: In a large single-institution experience, we find that plasma NGS results can routinely be expected within 2 weeks, but uncommonly result within 1 week, supporting the need for new strategies to incorporate plasma NGS into the initial genotyping of advanced non-small-cell lung cancer.","journal":"JCO Precision Oncology","year":2020,"id":100204,"datarank":1.4795866448885053,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.9694070376391819,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.9694070376391819,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":28,"citers_with_citation_signal":25,"citers_with_endowment":25,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":493125,"name":"Evan W. Clark","orcid":null,"position":1,"is_corresponding":false},{"id":244198,"name":"Marina S.D. Milan","orcid":null,"position":2,"is_corresponding":false},{"id":493126,"name":"Christine Champagne","orcid":null,"position":3,"is_corresponding":false},{"id":492212,"name":"Kesi Michael","orcid":"0000-0002-0899-9790","position":4,"is_corresponding":false},{"id":227614,"name":"Mark M. Awad","orcid":"0000-0003-0928-5244","position":5,"is_corresponding":false},{"id":227617,"name":"David A. Barbie","orcid":"0000-0002-5422-4275","position":6,"is_corresponding":false},{"id":438234,"name":"Michael L. Cheng","orcid":"0000-0002-7409-288X","position":7,"is_corresponding":false},{"id":492213,"name":"Kenneth L. Kehl","orcid":"0000-0001-5339-9797","position":8,"is_corresponding":false},{"id":492214,"name":"Judith Marcoux","orcid":"0000-0002-7000-642X","position":9,"is_corresponding":false},{"id":492215,"name":"Michael S. Rabin","orcid":"0000-0003-2491-5451","position":10,"is_corresponding":false},{"id":492216,"name":"Julia Rotow","orcid":"0000-0003-4547-2960","position":11,"is_corresponding":false},{"id":492217,"name":"Jacob Sands","orcid":"0000-0003-4663-7464","position":12,"is_corresponding":false},{"id":35301,"name":"Pasi A. Jänne","orcid":"0000-0002-7821-4928","position":13,"is_corresponding":false},{"id":71265,"name":"Geoffrey R. Oxnard","orcid":"0000-0003-1054-8240","position":14,"is_corresponding":false},{"id":492211,"name":"Yi Lee","orcid":"0000-0002-9092-1932","position":0,"is_corresponding":true}],"reference_count":9,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T22:38:35.493878Z","pmid":"33015530","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}