{"doi":"10.1200/op.24.00031","title":"Leveraging Mobile Health to Improve Capecitabine Adherence Among Women With Breast Cancer: A Pilot Randomized Controlled Trial","abstract":"PURPOSE Oral capecitabine improves convenience compared to intravenous therapies but presents monitoring challenges. We conducted a randomized pilot trial to evaluate a mobile health intervention to remotely monitor capecitabine adherence and patient-reported outcomes (PROs) among women with breast cancer. METHODS Patients with breast cancer prescribed capecitabine, an oral chemotherapy with a complex, cyclical regimen, were randomly assigned to enhanced usual care (EUC) or PRO arm. Participants were asked to use a smart pill bottle to measure adherence (timing and dose) and complete baseline and 90-day follow-up surveys. PRO participants received text messages for missed or incorrect doses and weekly text-based symptom assessments, and their oncologists received alerts for severe symptoms or missed doses. We compared nonadherence (<80%) and changes from enrollment to follow-up on reported physical and mental health quality-of-life scores and number of severe symptoms by study arm. RESULTS Overall, 32 women were randomly assigned (17 EUC and 15 PRO): 28 (87.5%) received the intervention and 24 (78.1%) completed the follow-up survey. Among participants who received the intervention, PRO participants responded to 83.3% of symptom questions; 7.7% of PRO participants were nonadherent compared with 40.0% of EUC participants ( P = .049). Among those who completed the follow-up survey, 12.5% of PRO participants had reductions in their mental health composite scores compared with 69.2% of EUC participants ( P = .011); 10% of PRO participants had more severe symptoms at follow-up compared with 57.1% of EUC participants ( P = .019). CONCLUSION A mobile health intervention using text message reminders and symptom assessments improved medication adherence and mental health quality-of-life scores and lowered symptom burden of patients with breast cancer prescribed capecitabine. Future work should evaluate the longer-term impacts of this intervention.","journal":"JCO Oncology Practice","year":2024,"id":451555,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["STUDY00002985"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1114152,"name":"Samuel Hernández","orcid":null,"position":1,"is_corresponding":false},{"id":1266641,"name":"Sara Arshad","orcid":"0009-0009-0754-3159","position":2,"is_corresponding":false},{"id":1272989,"name":"Kristina Byers","orcid":"0009-0001-8519-6465","position":3,"is_corresponding":false},{"id":444965,"name":"Jane Meisel","orcid":"0000-0002-2642-865X","position":4,"is_corresponding":false},{"id":574694,"name":"Gelareh Sadigh","orcid":"0000-0003-3233-1878","position":5,"is_corresponding":false},{"id":1272990,"name":"Elizabeth Sakach","orcid":"0000-0002-3295-0612","position":6,"is_corresponding":false},{"id":475798,"name":"Keerthi Gogineni","orcid":"0000-0002-9822-797X","position":7,"is_corresponding":false},{"id":444967,"name":"Mylin A. Torres","orcid":"0000-0003-3582-5216","position":8,"is_corresponding":false},{"id":767883,"name":"Ilana Graetz","orcid":"0000-0003-3664-5815","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:02:45.951080Z","pmid":"38917401","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}