{"doi":"10.1200/op.23.00040","title":"Disparities in Diagnosis, Treatment Access, and Time to Treatment Among Hispanic Men With Metastatic Prostate Cancer","abstract":"<jats:sec><jats:title>PURPOSE</jats:title><jats:p> Reporting racial/ethnic disparities in aggregate obscures within-group heterogeneity. We sought to identify disparities in diagnosis and treatment in Hispanic subpopulations with metastatic prostate cancer (mPCa). </jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p> We disaggregated men with prostate adenocarcinoma from the National Cancer Database from 2004 to 2017 by racial subgroup and Hispanic background. We assessed (1) presenting with mPCa, (2) receiving any treatment, and (3) receiving delayed treatment beyond 90 days. Logistic regression and adjusted odds ratios (aOR) were reported. </jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p> Hispanic men had greater odds of presenting with mPCa (aOR, 1.54; 95% CI, 1.50 to 1.58; P &lt; .001) compared with non-Hispanic White (NHW) men. All Hispanic racial subgroups were more likely to present with mPCa, with the highest risk in Hispanic Black (HB) men (aOR, 1.68; 95% CI, 1.46 to 1.93; P &lt; .01). Men from all Hispanic backgrounds had higher odds of presenting with mPCa, especially Mexican men (aOR, 1.99; 95% CI, 1.86 to 2.12; P &lt; .01). Hispanic men were less likely to receive any treatment (aOR, 0.60; 95% CI, 0.53 to 0.67; P &lt; .001), and this effect was particularly strong for Hispanic White patients (aOR, 0.58; 95% CI, 0.52 to 0.66; P &lt; .001) and Dominican men (aOR, 0.52; 95% CI, 0.28 to 0.98; P = .044). Hispanic men were more likely to experience treatment delays compared with NHW men (aOR, 1.38; 95% CI, 1.26 to 1.52; P &lt; .001) and in particular HB (aOR, 1.83; 95% CI, 1.22 to 2.75; P = .002) and South/Central American men (aOR, 1.48; 95% CI, 1.07 to 2.04; P = .018). </jats:p></jats:sec><jats:sec><jats:title>CONCLUSION</jats:title><jats:p> Differences exist in stage at presentation, treatment receipt, and delays in treatment on disaggregation by racial subgroup and Hispanic heritage. We need to study the potential mechanisms of the observed variations to help develop targeted interventions. </jats:p></jats:sec>","journal":"JCO Oncology Practice","year":2023,"id":611505,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":797187,"name":"Nishwant Swami","orcid":"0000-0002-3825-8678","position":1,"is_corresponding":false},{"id":339799,"name":"Edward Christopher Dee","orcid":"0000-0001-6119-0889","position":2,"is_corresponding":false},{"id":259325,"name":"Mohammed Alshalalfa","orcid":"0000-0001-8405-3035","position":3,"is_corresponding":false},{"id":1490152,"name":"Karthik Meiyappan","orcid":"0000-0002-2999-3937","position":4,"is_corresponding":false},{"id":973762,"name":"Narjust Duma","orcid":"0000-0002-7814-1773","position":5,"is_corresponding":false},{"id":368869,"name":"Frank J. Penedo","orcid":"0000-0002-2780-0417","position":6,"is_corresponding":false},{"id":262595,"name":"Paul L. Nguyen","orcid":"0000-0003-4268-3973","position":7,"is_corresponding":false},{"id":920570,"name":"Sanoj Punnen","orcid":"0000-0002-0383-7311","position":8,"is_corresponding":false},{"id":292146,"name":"Brandon A. Mahal","orcid":"0000-0001-5406-3232","position":9,"is_corresponding":false},{"id":843822,"name":"Helen Y. Hougen","orcid":"0000-0003-3141-6474","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Disparities in Diagnosis, Treatment Access, and Time to Treatment Among Hispanic Men With Metastatic Prostate Cancer","abstract":"<jats:sec><jats:title>PURPOSE</jats:title><jats:p> Reporting racial/ethnic disparities in aggregate obscures within-group heterogeneity. We sought to identify disparities in diagnosis and treatment in Hispanic subpopulations with metastatic prostate cancer (mPCa). </jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p> We disaggregated men with prostate adenocarcinoma from the National Cancer Database from 2004 to 2017 by racial subgroup and Hispanic background. We assessed (1) presenting with mPCa, (2) receiving any treatment, and (3) receiving delayed treatment beyond 90 days. Logistic regression and adjusted odds ratios (aOR) were reported. </jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p> Hispanic men had greater odds of presenting with mPCa (aOR, 1.54; 95% CI, 1.50 to 1.58; P &lt; .001) compared with non-Hispanic White (NHW) men. All Hispanic racial subgroups were more likely to present with mPCa, with the highest risk in Hispanic Black (HB) men (aOR, 1.68; 95% CI, 1.46 to 1.93; P &lt; .01). Men from all Hispanic backgrounds had higher odds of presenting with mPCa, especially Mexican men (aOR, 1.99; 95% CI, 1.86 to 2.12; P &lt; .01). Hispanic men were less likely to receive any treatment (aOR, 0.60; 95% CI, 0.53 to 0.67; P &lt; .001), and this effect was particularly strong for Hispanic White patients (aOR, 0.58; 95% CI, 0.52 to 0.66; P &lt; .001) and Dominican men (aOR, 0.52; 95% CI, 0.28 to 0.98; P = .044). Hispanic men were more likely to experience treatment delays compared with NHW men (aOR, 1.38; 95% CI, 1.26 to 1.52; P &lt; .001) and in particular HB (aOR, 1.83; 95% CI, 1.22 to 2.75; P = .002) and South/Central American men (aOR, 1.48; 95% CI, 1.07 to 2.04; P = .018). </jats:p></jats:sec><jats:sec><jats:title>CONCLUSION</jats:title><jats:p> Differences exist in stage at presentation, treatment receipt, and delays in treatment on disaggregation by racial subgroup and Hispanic heritage. We need to study the potential mechanisms of the observed variations to help develop targeted interventions. </jats:p></jats:sec>","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37262399","pmcid":"PMC10424902","openalex_id":"https://openalex.org/W4378975444","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"P30 CA008748","title":null}],"total_grants":1,"fwci":2.8125,"citation_percentile":0.9172366,"influential_citations":0,"citation_trend":[{"year":2024,"count":7},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10424902/pdf/op-19-645.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10424902/pdf/op-19-645.pdf","host_type":"repository"},{"url":"https://ascopubs.org/doi/pdfdirect/10.1200/OP.23.00040","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10424902","host_type":"repository"},{"url":"https://doi.org/10.1200/op.23.00040","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37262399","host_type":"repository"}],"fields_of_study":["Prostate Cancer Diagnosis and Treatment","Prostate Cancer Treatment and Research","Cancer survivorship and care"],"mesh_terms":["White","Black or African American","Hispanic or Latino","Humans","Male","Prostatic Neoplasms","Healthcare Disparities","Time-to-Treatment"],"keywords":["Medicine","Odds ratio","Prostate cancer","Odds","Logistic regression","Demography","Ethnic group","Internal medicine","Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T20:09:32.635498Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}