{"doi":"10.1200/op.22.00852","title":"Association of Patient-Reported Health-Related Quality of Life With Physician-Reported Toxicities in Adolescents and Young Adults Receiving Radiation Therapy for Cancer","abstract":"PURPOSE Radiation therapy (RT) may cause toxicities in adolescents and young adults (AYAs, age 15-39 years) with cancer. However, the range of RT-related toxicities in AYAs and the affect on health-related quality of life (HRQOL) has not been well studied. We performed a cross-sectional study in AYAs with cancer who received RT to identify RT-related toxicities and examine their impact on HRQOL. MATERIALS AND METHODS A total of 178 AYAs received RT and completed PROMIS HRQOL instruments from 2018 to 2022. Acute and late physician-graded Common Terminology Criteria for Adverse Events RT–related toxicities were extracted and described. Multivariable linear regression was used to evaluate the association of RT-related toxicity with HRQOL scores during and post-RT. Minimally important differences were used to evaluate the clinical relevance of relationships. RESULTS Eighty-four AYAs completed HRQOL surveys during RT and 94 post-RT. In the during-RT cohort, 75 AYAs (89%) had acute RT-related toxicities, a majority of which were grade 1 (n = 49, 65%). AYAs who experienced acute grade 2 or greater toxicities reported worse global mental health ( B = –7.35, P < .01) and worse pain ( B = 5.25, P = .01) than those with acute grade 1 or no toxicities. In the post-RT cohort, the median (IQR) time from RT to survey completion was 24 (14-27) months. Forty-eight AYAs (51%) had late RT-related toxicities, a majority of which were grade 1 (n = 37, 77%). AYAs who experienced late grade 2 or greater toxicities reported worse global mental health ( B = –8.07, P = .01), worse social roles ( B = –9.96, P < .01), and greater sleep disturbance ( B = 10.75, P < .01) than those with late grade 1 or no RT toxicities. CONCLUSION The presence of acute and late grade 2 or greater RT-related toxicities may contribute to worse HRQOL, especially global mental health, in AYAs. Screening and early interventions to mitigate RT-related toxicities are needed to improve AYA HRQOL.","journal":"JCO Oncology Practice","year":2023,"id":352691,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":282778,"name":"Bryce B. Reeve","orcid":"0000-0002-6709-8714","position":1,"is_corresponding":false},{"id":302778,"name":"John M. Salsman","orcid":"0000-0003-2317-4006","position":2,"is_corresponding":false},{"id":325681,"name":"Elizabeth J. Siembida","orcid":"0000-0003-1131-8359","position":3,"is_corresponding":false},{"id":380273,"name":"Grace L. Smith","orcid":"0000-0002-3171-2911","position":4,"is_corresponding":false},{"id":528452,"name":"Maria C. Swartz","orcid":"0000-0002-4069-3089","position":5,"is_corresponding":false},{"id":1098990,"name":"Kamaria L. Lee","orcid":null,"position":6,"is_corresponding":false},{"id":1098536,"name":"Faraz Afridi","orcid":"0000-0002-1645-1450","position":7,"is_corresponding":false},{"id":1098537,"name":"Lauren M. Andring","orcid":"0000-0001-8932-8560","position":8,"is_corresponding":false},{"id":692816,"name":"Andrew J. Bishop","orcid":"0000-0002-7737-8023","position":9,"is_corresponding":false},{"id":388065,"name":"Jillian R. Gunther","orcid":"0000-0001-5727-7594","position":10,"is_corresponding":false},{"id":374607,"name":"J. Andrew Livingston","orcid":"0000-0002-1337-3282","position":11,"is_corresponding":false},{"id":405093,"name":"Susan K. Peterson","orcid":"0000-0003-4793-1913","position":12,"is_corresponding":false},{"id":539568,"name":"Susan K. Parsons","orcid":"0000-0003-0282-6490","position":13,"is_corresponding":false},{"id":501723,"name":"Michael Roth","orcid":"0000-0002-6411-8353","position":14,"is_corresponding":false},{"id":449670,"name":"Kelsey L. Corrigan","orcid":"0000-0003-0314-6972","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T01:12:54.209378Z","pmid":"37311165","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}