{"doi":"10.1200/op.22.00037","title":"Implementation Strategies to Increase Clinical Trial Enrollment in a Community-Academic Partnership and Impact on Hispanic Representation: An Interrupted Time Series Analysis","abstract":"PURPOSE: Community-academic partnerships have the potential to improve access to clinical trials for under-represented minority patients who more often receive cancer treatment in community settings. In 2017, the Memorial Sloan Kettering (MSK) Cancer Center began opening investigator-initiated clinical trials in radiation oncology in targeted community-based partner sites with a high potential to improve diverse population accrual. This study evaluates the effectiveness of a set of implementation strategies for increasing overall community-based enrollment and the resulting proportional enrollment of Hispanic patients on trials on the basis of availability in community-based partner sites. METHODS: An interrupted time series analysis evaluating implementation strategies was conducted from April 2018 to September 2021. Descriptive analysis ofHispanic enrollment on investigator-initiated randomized therapeutic radiation trials open at community-based sites was compared with those open only at themain academic center. RESULTS: Overall, 84 patients were enrolled in clinical trials in the MSK Alliance, of which 48 (56%) identified as Hispanic. The quarterly patient enrollment pre- vs postimplementation increased from 1.39 (95% CI, -3.67 to 6.46) to 9.42 (95% CI, 2.05 to 16.78; P5 .017). In the investigator-initiated randomized therapeutic radiation trials open in the MSK Alliance, Hispanic representation was 11.5% and 35.9% in twometastatic trials and 14.2% in a proton versus photon trial. Inmatched trials open only at the main academic center, Hispanic representation was 5.6%, 6.0%, and 4.0%, respectively. CONCLUSION: A combination of practice-level and physician-level strategies implemented at community-based partner sites was associated with increased clinical trial enrollment, which translated to improved Hispanic representation. This supports the role Q:2 of strategic community-academic partnerships in addressing disparities in clinical trial enrollment.","journal":"JCO Oncology Practice","year":2022,"id":249897,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":890779,"name":"Diana Lin","orcid":"0000-0002-1173-0725","position":1,"is_corresponding":false},{"id":332026,"name":"Daniel R. Gomez","orcid":"0009-0003-8617-3868","position":2,"is_corresponding":false},{"id":281406,"name":"Jonathan T. Yang","orcid":"0000-0001-9375-7384","position":3,"is_corresponding":false},{"id":255810,"name":"Nancy Y. Lee","orcid":"0000-0003-3044-9522","position":4,"is_corresponding":false},{"id":241186,"name":"Andreas Rimner","orcid":"0000-0002-1214-3856","position":5,"is_corresponding":false},{"id":288024,"name":"Yoshiya Yamada","orcid":"0000-0003-1212-2331","position":6,"is_corresponding":false},{"id":343935,"name":"Michael J. Zeléfsky","orcid":"0000-0002-6090-6424","position":7,"is_corresponding":false},{"id":382749,"name":"Noah S. Kalman","orcid":"0000-0003-1299-3014","position":8,"is_corresponding":false},{"id":891222,"name":"Charles E. Rutter","orcid":null,"position":9,"is_corresponding":false},{"id":847719,"name":"Rupesh Kotecha","orcid":"0000-0001-6927-0402","position":10,"is_corresponding":false},{"id":259435,"name":"Minesh P. Mehta","orcid":"0000-0002-4812-5713","position":11,"is_corresponding":false},{"id":693165,"name":"Joseph Panoff","orcid":null,"position":12,"is_corresponding":false},{"id":259432,"name":"Michael D. Chuong","orcid":"0000-0001-8328-7518","position":13,"is_corresponding":false},{"id":333530,"name":"Andrew Salner","orcid":"0000-0002-3145-2953","position":14,"is_corresponding":false},{"id":309036,"name":"Jamie S. Ostroff","orcid":"0000-0003-2671-5680","position":15,"is_corresponding":false},{"id":427959,"name":"Lisa C. Diamond","orcid":"0000-0002-2175-6224","position":16,"is_corresponding":false},{"id":542384,"name":"Noah J. Mathis","orcid":"0000-0003-1125-6282","position":17,"is_corresponding":false},{"id":280062,"name":"Oren Cahlon","orcid":null,"position":18,"is_corresponding":false},{"id":255809,"name":"David G. Pfister","orcid":"0000-0002-2109-3221","position":19,"is_corresponding":false},{"id":255795,"name":"Zhigang Zhang","orcid":"0000-0001-8666-1026","position":20,"is_corresponding":false},{"id":293159,"name":"Fumiko Chino","orcid":"0000-0003-0498-488X","position":21,"is_corresponding":false},{"id":891223,"name":"Jillian Tsai","orcid":null,"position":22,"is_corresponding":false},{"id":278264,"name":"Erin F. Gillespie","orcid":"0000-0002-1386-1542","position":23,"is_corresponding":false},{"id":890778,"name":"Nahomy Ledesma Vicioso","orcid":"0000-0003-2294-3352","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T00:24:23.754337Z","pmid":"35544650","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}