{"doi":"10.1200/op.21.00169","title":"Longitudinal Experience With and Impressions of COVID-19–Related Clinical Research Changes","abstract":"PURPOSE: The COVID-19 pandemic has led to profound changes in clinical research, including remote consent, telehealth, off-site procedures, shipment of therapy, and remote study monitoring. We assessed longitudinal perceptions of these adjustments among clinical research professionals. METHODS: We distributed an anonymous survey assessing experiences, perceptions, and recommendations regarding COVID-19–related clinical research adjustments to cancer clinical research office personnel in May 2020 and again in November 2020. Responses were compared using Fisher's exact and Mann-Whitney U tests. RESULTS: A total of 90 of 102 invited research personnel (88%) responded. Fifty-three (59%) reported participating in both initial and follow-up surveys. The proportion of respondents reporting personal experience with COVID-19–related adjustments increased over time, particularly for remote initial consent (29% v 4%), remote reconsent (24% v 9%), and remote study monitoring (36% v 22%). Perceived impact of COVID-19–related adjustments on data quality ( P = .02) and patient experience ( P = .002) improved significantly. However, perceived effect on patient safety ( P = .02) and respondent's experience ( P = .09) became less favorable. Individuals with personal experience with the adjustment were more likely to recommend continuing remote consent (62% v 38%; P = .04), remote monitoring (69% v 45%; P = .05), and therapy shipment (67% v 35%; P = .01) after the COVID-19 pandemic, with nonsignificant trends for off-site diagnostics (44% v 24%; P = .13) and telehealth visits (66% v 45%; P = .08). CONCLUSION: More than 6 months into the global pandemic, perceptions of COVID-19–related clinical research changes remain favorable. Experienced individuals are more likely to recommend that these changes continue in the future.","journal":"JCO Oncology Practice","year":2021,"id":200297,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":712925,"name":"Valerie L. Clark","orcid":"0000-0003-2277-4296","position":1,"is_corresponding":false},{"id":352534,"name":"Thomas Sheffield","orcid":"0000-0001-9073-6334","position":2,"is_corresponding":false},{"id":107742,"name":"Muhammad Shaalan Beg","orcid":"0000-0002-3754-6627","position":3,"is_corresponding":false},{"id":326811,"name":"Yang Xie","orcid":"0000-0001-9456-1762","position":4,"is_corresponding":false},{"id":712926,"name":"M. E. Blair Holbein","orcid":"0000-0003-1368-4571","position":5,"is_corresponding":false},{"id":329851,"name":"Celette Sugg Skinner","orcid":"0000-0002-2535-4476","position":6,"is_corresponding":false},{"id":317122,"name":"Simon J. Craddock Lee","orcid":"0000-0001-6345-1237","position":7,"is_corresponding":false},{"id":712924,"name":"Erin L. Williams","orcid":"0000-0003-4357-4111","position":8,"is_corresponding":false},{"id":1553,"name":"David E. Gerber","orcid":"0000-0002-7812-6741","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-18T23:50:44.479665Z","pmid":"34324403","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}