{"doi":"10.1200/jco.24.00048","title":"Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer","abstract":"<jats:sec>\n            <jats:title>PURPOSE</jats:title>\n            <jats:p>In patients with lung cancer, dyspnea is one of the most prevalent and disabling symptoms, for which effective treatments are lacking. We examined the efficacy of a nurse-led brief behavioral intervention to improve dyspnea in patients with advanced lung cancer.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>METHODS</jats:title>\n            <jats:p>Patients with advanced lung cancer reporting at least moderate breathlessness (n = 247) were enrolled in a randomized trial of a nurse-led two-session intervention (focused on breathing techniques, postural positions, and fan therapy) versus usual care. At baseline and weeks 8 (primary end point), 16, and 24, participants completed measures of dyspnea (Modified Medical Research Council Dyspnea Scale [mMRCDS]; Cancer Dyspnoea Scale [CDS]), quality of life (Functional Assessment of Cancer Therapy-Lung [FACT-L]), psychological symptoms (Hospital Anxiety and Depression Scale), and activity level (Godin-Shephard Leisure Time Physical Activity Questionnaire). To examine intervention effects, we conducted analysis of covariance and longitudinal mixed effects models.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS</jats:title>\n            <jats:p>\n              The sample (Age\n              <jats:sub>mean</jats:sub>\n              = 66.15 years; 55.9% female) primarily included patients with advanced non–small cell lung cancer (85.4%). Compared with usual care, the intervention improved the primary outcome of patient-reported dyspnea on the mMRCDS (difference = –0.33 [95% CI, –0.61 to –0.05]) but not the CDS total score at 8 weeks. Intervention patients also reported less dyspnea on the CDS sense of discomfort subscale (difference = –0.59 [95% CI, –1.16 to –0.01]) and better functional well-being per the FACT-L (difference = 1.39 [95% CI, 0.18 to 2.59]) versus the control group. Study groups did not differ in overall quality of life, psychological symptoms, or activity level at 8 weeks or longitudinally over 24 weeks.\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION</jats:title>\n            <jats:p>For patients with advanced lung cancer, a scalable behavioral intervention alleviated the intractable symptom of dyspnea. Further research is needed on ways to enhance intervention effects over the long-term and across additional outcomes.</jats:p>\n          </jats:sec>","journal":"Journal of Clinical Oncology","year":2024,"id":655297,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":826621,"name":"Kathryn Post","orcid":"0000-0002-1777-5158","position":1,"is_corresponding":false},{"id":1710544,"name":"Reena Chabria","orcid":"0009-0005-5938-9254","position":2,"is_corresponding":false},{"id":1285249,"name":"Seetha Aribindi","orcid":"0000-0001-5344-4455","position":3,"is_corresponding":false},{"id":1710545,"name":"Natalie Brennan","orcid":null,"position":4,"is_corresponding":false},{"id":1086566,"name":"Ijeoma Julie Eche","orcid":"0000-0002-9024-6228","position":5,"is_corresponding":false},{"id":573725,"name":"Barbara Halpenny","orcid":"0000-0001-6273-8674","position":6,"is_corresponding":false},{"id":788279,"name":"Erica Fox","orcid":null,"position":7,"is_corresponding":false},{"id":1421555,"name":"Stephen Lo","orcid":"0000-0002-7094-8898","position":8,"is_corresponding":false},{"id":1710546,"name":"Lauren P. Waldman","orcid":null,"position":9,"is_corresponding":false},{"id":1105237,"name":"Kedie Pintro","orcid":null,"position":10,"is_corresponding":false},{"id":418744,"name":"Dustin J. Rabideau","orcid":"0000-0002-3829-7079","position":11,"is_corresponding":false},{"id":362067,"name":"William F. Pirl","orcid":"0000-0001-5226-9886","position":12,"is_corresponding":false},{"id":829922,"name":"Mary E. Cooley","orcid":"0000-0001-5353-9542","position":13,"is_corresponding":false},{"id":461670,"name":"Jennifer S. Temel","orcid":"0000-0002-7268-5921","position":14,"is_corresponding":false},{"id":497885,"name":"Joseph A. Greer","orcid":"0000-0002-0979-4076","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Randomized Controlled Trial of a Nurse-Led Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer","abstract":"<jats:sec>\n            <jats:title>PURPOSE</jats:title>\n            <jats:p>In patients with lung cancer, dyspnea is one of the most prevalent and disabling symptoms, for which effective treatments are lacking. We examined the efficacy of a nurse-led brief behavioral intervention to improve dyspnea in patients with advanced lung cancer.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>METHODS</jats:title>\n            <jats:p>Patients with advanced lung cancer reporting at least moderate breathlessness (n = 247) were enrolled in a randomized trial of a nurse-led two-session intervention (focused on breathing techniques, postural positions, and fan therapy) versus usual care. At baseline and weeks 8 (primary end point), 16, and 24, participants completed measures of dyspnea (Modified Medical Research Council Dyspnea Scale [mMRCDS]; Cancer Dyspnoea Scale [CDS]), quality of life (Functional Assessment of Cancer Therapy-Lung [FACT-L]), psychological symptoms (Hospital Anxiety and Depression Scale), and activity level (Godin-Shephard Leisure Time Physical Activity Questionnaire). To examine intervention effects, we conducted analysis of covariance and longitudinal mixed effects models.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS</jats:title>\n            <jats:p>\n              The sample (Age\n              <jats:sub>mean</jats:sub>\n              = 66.15 years; 55.9% female) primarily included patients with advanced non–small cell lung cancer (85.4%). Compared with usual care, the intervention improved the primary outcome of patient-reported dyspnea on the mMRCDS (difference = –0.33 [95% CI, –0.61 to –0.05]) but not the CDS total score at 8 weeks. Intervention patients also reported less dyspnea on the CDS sense of discomfort subscale (difference = –0.59 [95% CI, –1.16 to –0.01]) and better functional well-being per the FACT-L (difference = 1.39 [95% CI, 0.18 to 2.59]) versus the control group. Study groups did not differ in overall quality of life, psychological symptoms, or activity level at 8 weeks or longitudinally over 24 weeks.\n            </jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION</jats:title>\n            <jats:p>For patients with advanced lung cancer, a scalable behavioral intervention alleviated the intractable symptom of dyspnea. Further research is needed on ways to enhance intervention effects over the long-term and across additional outcomes.</jats:p>\n          </jats:sec>","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39088766","pmcid":"PMC11483213","openalex_id":"https://openalex.org/W4401209006","authors":[],"funders":[{"funder_name":"NINR NIH HHS","grant_id":"R01 NR016694","title":null}],"total_grants":1,"fwci":4.7568,"citation_percentile":0.95949417,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":8},{"year":2026,"count":8}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11483213/pdf/nihms-1994042.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11483213/pdf/nihms-1994042.pdf","host_type":"repository"},{"url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.24.00048","host_type":"publisher"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11483213/","host_type":"repository"},{"url":"https://doi.org/10.1200/jco.24.00048","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39088766","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11483213","host_type":"repository"}],"fields_of_study":["Chronic Obstructive Pulmonary Disease (COPD) Research","Cancer survivorship and care","Delphi Technique in Research"],"mesh_terms":["Aged","Behavior Therapy","Dyspnea","Female","Humans","Lung Neoplasms","Male","Middle Aged","Neoplasm Staging","Nurses","Quality of Life"],"keywords":["Medicine","Randomized controlled trial","Lung cancer","Physical therapy","Quality of life (healthcare)","Anxiety","Hospital Anxiety and Depression Scale","Cancer","Depression (economics)","Intervention (counseling)","Internal medicine","Nursing","Psychiatry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T10:22:08.969119Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}