{"doi":"10.1200/jco.20.02422","title":"Reply to L. C. Mendez et al and M. A. Kollmeier et al","abstract":"Prostate Cancer: A Network Meta-Analysis of Randomized Trials.\" 3 The points they have raised reinforce our overarching drive for the above-mentioned study: Changes in practice substantiated by the use of lowerquality evidence can result in unintended consequences.We would like to underscore some fundamental principles in this reply.The goal of treatment is to help patients live better (quality) or longer (quantity).In localized prostate cancer (PCa), to improve overall survival (OS), treatment must reduce PCa-specific mortality (PCSM).The predominant cause of PCSM is a manifestation of the development of distant metastases (DMs).Thus, for an oncologic treatment to improve OS in men with localized PCa, in nearly all scenarios, the treatment must result in, at a minimum, a reduction in the risk of developing DMs.This concept is supported by the analysis performed by the Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP) working group, which demonstrated that the most suitable surrogate end point for OS in localized PCa is metastasisfree survival. 4,","journal":"Journal of Clinical Oncology","year":2020,"id":131170,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":390399,"name":"Holly Hartman","orcid":"0000-0002-9101-4381","position":1,"is_corresponding":false},{"id":393051,"name":"Robert T. Dess","orcid":"0000-0003-2331-3758","position":2,"is_corresponding":false},{"id":262580,"name":"Daniel E. Spratt","orcid":"0000-0002-5973-4741","position":3,"is_corresponding":false},{"id":398139,"name":"Will Jackson","orcid":"0000-0001-8709-5978","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-18T23:16:00.235845Z","pmid":"32997578","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}