{"doi":"10.1200/jco.20.00265","title":"Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor Transplantation","abstract":"PURPOSE: The main aim of this study was to evaluate the significance of HLA-DPB1 expression in acute graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT) from HLA-A, -B, -C, -DRB1, -DQB1-matched and -mismatched unrelated donors. PATIENTS AND METHODS: Between January 1, 2017, and January 10, 2019, we assessed 19,136 patients who received HCT from an HLA-A, -B, -C, -DRB1, -DQB1-matched or -mismatched unrelated donor performed in Australia, the European Union, Japan, North America, and the United Kingdom between 1988 and 2016. Among transplant recipients with one HLA-DPB1 mismatch, the patient's mismatched HLA-DPB1 allotype was defined as low or high expression. Multivariable regression models were used to assess risks of GVHD associated with high expression relative to low expression HLA-DPB1 mismatches. The effect of increasing numbers of HLA-DPB1 mismatches on clinical outcome was assessed in HLA-mismatched transplant recipients. RESULTS: = .0016) relative to low-expression patient mismatches, regardless of the expression level of the donor's mismatched HLA-DPB1. Among transplant recipients with one HLA-A, -B, -C, -DRB1, or -DQB1 mismatch, the odds of acute GVHD increased with increasing numbers of HLA-DPB1 mismatches (OR, 1.23 for one; OR, 1.40 for two mismatches relative to zero mismatches for moderate GVHD; OR, 1.19 for one; OR, 1.40 for two mismatches relative to zero for severe GVHD), but not with the level of expression of the patient's mismatched HLA-DPB1 allotype. CONCLUSION: The level of expression of patient HLA-DPB1 mismatches informs the risk of GVHD after HLA-A, -B, -C, -DRB1, -DQB1-matched unrelated HCT, and the total number of HLA-DPB1 mismatches informs the risk of GVHD after HLA-mismatched unrelated HCT. Prospective consideration of HLA-DPB1 may help to lower GVHD risks after transplantation.","journal":"Journal of Clinical Oncology","year":2020,"id":59396,"datarank":0.6329261557764161,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":0.0,"self_endowment_contribution":0.6329261557764161,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8746,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":312328,"name":"Mats Bengtsson","orcid":"0000-0003-2612-0724","position":1,"is_corresponding":false},{"id":313248,"name":"Dianne De Santis","orcid":null,"position":2,"is_corresponding":false},{"id":312329,"name":"Valérie Dubois","orcid":"0000-0002-1169-7697","position":3,"is_corresponding":false},{"id":312330,"name":"Katharina Fleischhauer","orcid":"0000-0002-5827-8000","position":4,"is_corresponding":false},{"id":236737,"name":"Ted Gooley","orcid":"0000-0002-8182-3652","position":5,"is_corresponding":false},{"id":122977,"name":"Mary M. Horowitz","orcid":"0000-0002-9502-785X","position":6,"is_corresponding":false},{"id":312331,"name":"J. Alejandro Madrigal","orcid":"0000-0001-8359-9917","position":7,"is_corresponding":false},{"id":313249,"name":"Mari Malkki","orcid":null,"position":8,"is_corresponding":false},{"id":312332,"name":"Caroline McKallor","orcid":"0000-0003-2161-8259","position":9,"is_corresponding":false},{"id":202749,"name":"Yasuo Morishima","orcid":null,"position":10,"is_corresponding":false},{"id":313250,"name":"Machteld Oudshoorn","orcid":null,"position":11,"is_corresponding":false},{"id":122974,"name":"Stephen R. Spellman","orcid":"0000-0002-7271-8252","position":12,"is_corresponding":false},{"id":312333,"name":"Jean Villard","orcid":"0000-0003-2667-7506","position":13,"is_corresponding":false},{"id":313251,"name":"Phil Stevenson","orcid":null,"position":14,"is_corresponding":false},{"id":37727,"name":"Mary Carrington","orcid":"0000-0002-2692-2180","position":15,"is_corresponding":false},{"id":313252,"name":"on behalf of the","orcid":null,"position":16,"is_corresponding":false},{"id":313253,"name":"International Histocompatibility Working Group in Hematopoietic-Cell Transplantation","orcid":null,"position":17,"is_corresponding":false},{"id":312327,"name":"Effie W. Petersdorf","orcid":"0000-0002-6454-3683","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:07:59.189921Z","pmid":"32479188","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}