{"doi":"10.1200/cci.23.00024","title":"Development of an Electronic Health Record–Based Clinical Decision Support Tool for Patients With Lynch Syndrome","abstract":"PURPOSE: To develop an electronic health record (EHR)-based clinical decision support (CDS) tool to promote guideline-recommended cancer risk management among patients with Lynch syndrome (LS), an inherited cancer syndrome that confers an increased risk of colorectal and other cancer types. MATERIALS AND METHODS: We conducted a cross-sectional study to determine the baseline prevalence and predictors of guideline-recommended colonic surveillance and annual genetics program visits among patients with LS. Multivariable log-binomial regressions estimated prevalence ratios (PRs) of cancer risk management adherence by baseline sociodemographic and clinical characteristics. These analyses provided rationale for the development of an EHR-based CDS tool to support patients and clinicians with LS-related endoscopic surveillance and annual genetics program visits. The CDS leverages an EHR platform linking discrete genetic data to LS Genomic Indicators, in turn driving downstream clinician- and patient-facing CDS. RESULTS: Among 323 patients with LS, cross-sectional adherence to colonic surveillance and annual genetics program visits was 69.3% and 55.4%, respectively. Patients with recent electronic patient portal use were more likely to be adherent to colonic surveillance (PR, 1.67; 95% CI, 1.11 to 2.52). Patients more recently diagnosed with LS were more likely to be adherent to annual genetics program visits (PR, 0.58; 95% CI, 0.44 to 0.76 for 2-4 years; PR, 0.62; 95% CI, 0.51 to 0.75 for ≥4 compared with <2 years). Our EHR-based CDS tool is now active for 421 patients with LS throughout our health system. CONCLUSION: We have successfully developed an EHR-based CDS tool to promote guideline-recommended cancer risk management among patients with LS.","journal":"JCO Clinical Cancer Informatics","year":2023,"id":385308,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":870669,"name":"Joseph Bleznuck","orcid":null,"position":1,"is_corresponding":false},{"id":704469,"name":"Colin Wollack","orcid":null,"position":2,"is_corresponding":false},{"id":763276,"name":"Danielle McKenna","orcid":"0000-0002-8317-1520","position":3,"is_corresponding":false},{"id":474568,"name":"Jessica M. Long","orcid":"0000-0003-0382-7890","position":4,"is_corresponding":false},{"id":1153020,"name":"Anna P. Hubert","orcid":"0009-0001-6319-3108","position":5,"is_corresponding":false},{"id":1153383,"name":"Mariah Johnson","orcid":null,"position":6,"is_corresponding":false},{"id":1153384,"name":"Shavon E. Rochester","orcid":null,"position":7,"is_corresponding":false},{"id":763274,"name":"Gillain Constantino","orcid":"0000-0002-7997-7572","position":8,"is_corresponding":false},{"id":474567,"name":"Christina Dudzik","orcid":"0000-0001-5485-9804","position":9,"is_corresponding":false},{"id":263487,"name":"Abigail Doucette","orcid":"0000-0002-6646-433X","position":10,"is_corresponding":false},{"id":474569,"name":"Kirk J. Wangensteen","orcid":"0000-0001-6042-6490","position":11,"is_corresponding":false},{"id":78635,"name":"Susan M. Domchek","orcid":"0000-0002-5914-7272","position":12,"is_corresponding":false},{"id":321961,"name":"Jeffrey Landgraf","orcid":null,"position":13,"is_corresponding":false},{"id":320536,"name":"Jessica Chen","orcid":"0000-0002-8329-1741","position":14,"is_corresponding":false},{"id":95410,"name":"Katherine L. Nathanson","orcid":"0000-0002-6740-0901","position":15,"is_corresponding":false},{"id":245660,"name":"Bryson W. Katona","orcid":"0000-0001-8186-9119","position":16,"is_corresponding":false},{"id":320534,"name":"Kelsey S. Lau‐Min","orcid":"0000-0001-8854-224X","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:17:48.629718Z","pmid":"37639653","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}