{"doi":"10.1194/jlr.m900145-jlr200","title":"GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4","abstract":null,"journal":"Journal of Lipid Research","year":2009,"id":607798,"datarank":0.7254422860427218,"base_score":4.836281906951478,"endowment":4.836281906951478,"self_citation_contribution":0.7254422860427218,"citation_network_contribution":0.0,"self_endowment_contribution":0.7254422860427218,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":125,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1560775,"name":"Daiguan Yu","orcid":null,"position":1,"is_corresponding":false},{"id":225383,"name":"E-Chiang Lee","orcid":"0000-0002-7849-3648","position":2,"is_corresponding":false},{"id":1395894,"name":"Wei Xiong","orcid":"0009-0002-6560-6399","position":3,"is_corresponding":false},{"id":1560777,"name":"Gennady Gololobov","orcid":null,"position":4,"is_corresponding":false},{"id":1560778,"name":"Billie Key","orcid":null,"position":5,"is_corresponding":false},{"id":647146,"name":"Jason Gay","orcid":null,"position":6,"is_corresponding":false},{"id":1560779,"name":"Nat Wilganowski","orcid":null,"position":7,"is_corresponding":false},{"id":336340,"name":"Yi Hu","orcid":"0000-0002-5432-1438","position":8,"is_corresponding":false},{"id":1560780,"name":"Sharon Zhao","orcid":null,"position":9,"is_corresponding":false},{"id":1379628,"name":"Matthias Schneider","orcid":"0000-0002-2655-3709","position":10,"is_corresponding":false},{"id":1560781,"name":"Zhi-Ming Ding","orcid":null,"position":11,"is_corresponding":false},{"id":30792,"name":"Brian P. Zambrowicz","orcid":null,"position":12,"is_corresponding":false},{"id":1560782,"name":"Greg Landes","orcid":null,"position":13,"is_corresponding":false},{"id":1006757,"name":"David R. Powell","orcid":"0000-0003-0656-0124","position":14,"is_corresponding":false},{"id":738467,"name":"Urvi Desai","orcid":"0000-0001-5196-7201","position":15,"is_corresponding":false},{"id":1560772,"name":"William K. Sonnenburg","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4","abstract":"Glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) binds both LPL and chylomicrons, suggesting that GPIHBP1 is a platform for LPL-dependent processing of triglyceride (TG)-rich lipoproteins. Here, we investigated whether GPIHBP1 affects LPL activity in the absence and presence of LPL inhibitors angiopoietin-like (ANGPTL)3 and ANGPTL4. Like heparin, GPIHBP1 stabilized but did not activate LPL. ANGPTL4 potently inhibited nonstabilized LPL as well as heparin-stabilized LPL but not GPIHBP1-stabilized LPL. Like ANGPTL4, ANGPTL3 inhibited nonstabilized LPL but not GPIHBP1-stabilized LPL. ANGPTL3 also inhibited heparin-stabilized LPL but with less potency than nonstabilized LPL. Consistent with these in vitro findings, fasting serum TGs of Angptl4(-/-)/Gpihbp1(-/-) mice were lower than those of Gpihbp1(-/-) mice and approached those of wild-type littermates. In contrast, serum TGs of Angptl3(-/-)/Gpihbp1(-/-) mice were only slightly lower than those of Gpihbp1(-/-) mice. Treating Gpihbp1(-/-) mice with ANGPTL4- or ANGPTL3-neutralizing antibodies recapitulated the double knockout phenotypes. These data suggest that GPIHBP1 functions as an LPL stabilizer. Moreover, therapeutic agents that prevent LPL inhibition by ANGPTL4 or, to a lesser extent, ANGPTL3, may benefit individuals with hyperlipidemia caused by gene mutations associated with decreased LPL stability.","is_dataset_classified":null,"base_score":4.836281906951478,"endowment":4.836281906951478,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19542565","pmcid":"PMC2781314","openalex_id":"https://openalex.org/W2149487645","authors":[],"funders":[],"total_grants":0,"fwci":4.8077,"citation_percentile":0.95800445,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":5},{"year":2014,"count":9},{"year":2015,"count":8},{"year":2016,"count":11},{"year":2017,"count":6},{"year":2018,"count":10},{"year":2019,"count":13},{"year":2020,"count":7},{"year":2021,"count":11},{"year":2022,"count":5},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.jlr.org/article/S0022227520306659/pdf","host_type":"journal"},{"url":"http://www.jlr.org/article/S0022227520306659/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022227520306659?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022227520306659?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1194/jlr.M900145-JLR200","host_type":"publisher"},{"url":"https://doi.org/10.1194/jlr.m900145-jlr200","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19542565","host_type":"repository"},{"url":"https://doaj.org/article/212a1662bcbd4d06a66de9a15ab677ad","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2781314","host_type":"repository"},{"url":"http://www.jlr.org/cgi/content/abstract/50/12/2421","host_type":"www.jlr.org"},{"url":"http://www.jlr.org/cgi/reprint/50/12/2421.pdf","host_type":"www.jlr.org"},{"url":"http://www.jlr.org/cgi/content/full/50/12/2421","host_type":"www.jlr.org"}],"fields_of_study":["Lipid metabolism and disorders","Diabetes, Cardiovascular Risks, and Lipoproteins","Angiopoietin-Like Protein 3","Angiopoietin-Like Protein 4","Angiopoietin-like Proteins","Angiopoietins","Animals","Carrier Proteins","Cattle","Enzyme Stability","Humans","Lipoprotein Lipase","Mice","Mice, Knockout","Receptors, Lipoprotein","Recombinant Proteins"],"mesh_terms":["Angiopoietin-like Proteins","Angiopoietin-Like Protein 4","Angiopoietin-Like Protein 3","Animals","Carrier Proteins","Cattle","Enzyme Stability","Humans","Lipoprotein Lipase","Recombinant Proteins","Receptors, Lipoprotein","Mice, Knockout","Angiopoietins","Mice"],"keywords":["Lipoprotein lipase","ANGPTL4","Chylomicron","Chemistry","Endocrinology","Internal medicine","Pharmacology","Biochemistry","Biology","Lipoprotein","Gene","Enzyme","Medicine","Very low-density lipoprotein","Cholesterol"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:01:10.040130Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}