{"doi":"10.1192/bjp.bp.108.052050","title":"Diagnostic accuracy of <sup>123</sup>I-FP-CIT SPECT in possible dementia with Lewy bodies","abstract":"<jats:sec><jats:title>Background</jats:title><jats:p><jats:sup>123</jats:sup>I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>Our aim was to determine the accuracy of <jats:sup>123</jats:sup>I-FP-CIT SPECT in diagnosing people with possible dementia with Lewy bodies.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We undertook a 12-month follow-up of 325 individuals with probable or possible Lewy body or non-Lewy body dementia who had previously undergone <jats:sup>123</jats:sup>I-FP-CIT SPECT. A consensus panel masked to SPECT findings, established diagnosis at 12 months in 264 people.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 44 people with possible dementia with Lewy bodies at baseline, at follow-up the diagnosis for 19 people was probable dementia with Lewy bodies (43%), in 7 people non-Lewy body dementia (16%) and for 18 individuals it remained possible dementia with Lewy bodies (41%). Of the 19 who at follow-up were diagnosed with probable dementia with Lewy bodies, 12 had abnormal scans at baseline (sensitivity 63%); all 7 individuals with a possible diagnosis who were diagnosed as having Alzheimer's disease at follow-up had normal scans (specificity 100%).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our findings confirm the diagnostic accuracy of <jats:sup>123</jats:sup>I-FP-CIT SPECT in distinguishing Lewy body from non-Lewy body dementia and also suggest a clinically useful role in diagnostically uncertain cases, as an abnormal scan in a person with possible dementia with Lewy bodies is strongly suggestive of dementia with Lewy bodies.</jats:p></jats:sec>","journal":"British Journal of Psychiatry","year":2009,"id":591531,"datarank":4.173820429265251,"base_score":4.912654885736052,"endowment":4.912654885736052,"self_citation_contribution":0.736898232860408,"citation_network_contribution":3.4369221964048426,"self_endowment_contribution":0.736898232860408,"citer_contribution":3.4369221964048426,"corpus_percentile":null,"corpus_rank":null,"citation_count":135,"citer_count":95,"citers_with_citation_signal":76,"citers_with_endowment":76,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108583,"name":"Ian G. 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O'Brien","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Diagnostic accuracy of <sup>123</sup>I-FP-CIT SPECT in possible dementia with Lewy bodies","abstract":"<jats:sec><jats:title>Background</jats:title><jats:p><jats:sup>123</jats:sup>I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>Our aim was to determine the accuracy of <jats:sup>123</jats:sup>I-FP-CIT SPECT in diagnosing people with possible dementia with Lewy bodies.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We undertook a 12-month follow-up of 325 individuals with probable or possible Lewy body or non-Lewy body dementia who had previously undergone <jats:sup>123</jats:sup>I-FP-CIT SPECT. A consensus panel masked to SPECT findings, established diagnosis at 12 months in 264 people.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 44 people with possible dementia with Lewy bodies at baseline, at follow-up the diagnosis for 19 people was probable dementia with Lewy bodies (43%), in 7 people non-Lewy body dementia (16%) and for 18 individuals it remained possible dementia with Lewy bodies (41%). Of the 19 who at follow-up were diagnosed with probable dementia with Lewy bodies, 12 had abnormal scans at baseline (sensitivity 63%); all 7 individuals with a possible diagnosis who were diagnosed as having Alzheimer's disease at follow-up had normal scans (specificity 100%).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our findings confirm the diagnostic accuracy of <jats:sup>123</jats:sup>I-FP-CIT SPECT in distinguishing Lewy body from non-Lewy body dementia and also suggest a clinically useful role in diagnostically uncertain cases, as an abnormal scan in a person with possible dementia with Lewy bodies is strongly suggestive of dementia with Lewy bodies.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":4.912654885736052,"endowment":4.912654885736052,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19118323","pmcid":null,"openalex_id":"https://openalex.org/W2151958260","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"G0502157","title":null},{"funder_name":"Medical Research Council","grant_id":"G0400074","title":null}],"total_grants":2,"fwci":5.5725,"citation_percentile":0.96462809,"influential_citations":5,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":13},{"year":2014,"count":18},{"year":2015,"count":7},{"year":2016,"count":12},{"year":2017,"count":8},{"year":2018,"count":8},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":"https://www.cambridge.org/core/terms","oa_locations":[{"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/553C4C787456C7D8644CEB09A8FF2F7C/S0007125000015324a.pdf/div-class-title-diagnostic-accuracy-of-span-class-sup-123-span-i-fp-cit-spect-in-possible-dementia-with-lewy-bodies-div.pdf","host_type":"journal"},{"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/553C4C787456C7D8644CEB09A8FF2F7C/S0007125000015324a.pdf/div-class-title-diagnostic-accuracy-of-span-class-sup-123-span-i-fp-cit-spect-in-possible-dementia-with-lewy-bodies-div.pdf","host_type":"BRONZE"},{"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/553C4C787456C7D8644CEB09A8FF2F7C/S0007125000015324a.pdf/div-class-title-diagnostic-accuracy-of-span-class-sup-123-span-i-fp-cit-spect-in-possible-dementia-with-lewy-bodies-div.pdf","host_type":"publisher"},{"url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007125000015324","host_type":"publisher"},{"url":"https://doi.org/10.1192/bjp.bp.108.052050","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19118323","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/c70175be-15bc-4bc6-903d-ef16a1c98a78","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/diagnostic-accuracy-of-123ifpcit-spect-in-possible-dementia-with-lewy-bodies(e49689cf-03cd-4059-ba4f-207af471c2fe).html","host_type":"repository"}],"fields_of_study":["Dementia and Cognitive Impairment Research","Schizophrenia research and treatment","Epilepsy research and treatment","Psychology","Medicine"],"mesh_terms":["Aged","Aged, 80 and over","Female","Follow-Up Studies","Humans","Male","Middle Aged","Tropanes","Tomography, Emission-Computed, Single-Photon","Lewy Bodies","Radiopharmaceuticals","Lewy Body Disease"],"keywords":["Dementia with Lewy bodies","Dementia","Lewy body","Psychology","Medicine","Lewy body disease","Differential diagnosis","Disease","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T17:23:06.150534Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}