{"doi":"10.1189/jlb.1113599","title":"Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors","abstract":"<jats:title>Abstract</jats:title><jats:p>MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.</jats:p>","journal":"Journal of Leukocyte Biology","year":2014,"id":599605,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1492857,"name":"Jonathan W Yewdell","orcid":null,"position":1,"is_corresponding":false},{"id":1536707,"name":"Luis C Antón","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors","abstract":"<jats:title>Abstract</jats:title><jats:p>MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.</jats:p>","is_dataset_classified":null,"base_score":4.844187086458591,"endowment":4.844187086458591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24532645","pmcid":"PMC3958739","openalex_id":"https://openalex.org/W2141927426","authors":[],"funders":[{"funder_name":"The Centro de Biología Molecular Severo Ochoa","grant_id":"","title":null},{"funder_name":"Spanish Ministerio de Economía y Competitividad","grant_id":"","title":null},{"funder_name":"Division of Intramural Research","grant_id":"","title":null},{"funder_name":"Fundación Ramón Areces","grant_id":"","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases","grant_id":"","title":null},{"funder_name":"U.S. National Institutes of Health","grant_id":"","title":null}],"total_grants":6,"fwci":5.1989,"citation_percentile":0.96629184,"influential_citations":0,"citation_trend":[{"year":2014,"count":4},{"year":2015,"count":10},{"year":2016,"count":12},{"year":2017,"count":14},{"year":2018,"count":14},{"year":2019,"count":16},{"year":2020,"count":11},{"year":2021,"count":14},{"year":2022,"count":11},{"year":2023,"count":6},{"year":2024,"count":5},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/jleukbio/article-pdf/95/4/551/49583473/jlb0551.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1189/jlb.1113599","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24532645","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3958739","host_type":"repository"}],"fields_of_study":["vaccines and immunoinformatics approaches","Immunotherapy and Immune Responses","Immune Cell Function and Interaction","Animals","Antigen Presentation","Histocompatibility Antigens Class I","Humans","Mediator Complex","Monitoring, Immunologic","Neoplasms","Protein Biosynthesis","Ribosomes"],"mesh_terms":["Animals","Humans","Neoplasms","Ribosomes","Protein Biosynthesis","Monitoring, Immunologic","Histocompatibility Antigens Class I","Antigen Presentation","Mediator Complex"],"keywords":["Immunosurveillance","Biology","Haystack","MHC class I","Major histocompatibility complex","Translation (biology)","Computational biology","Intracellular","Cell biology","Cell","Immunology","Genetics","Antigen","Gene","Computer science","Translation","Ribosome","Antigen Processing","Compartmentalization","Nuclear Translation","Cotranslational Degradation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T10:49:45.338435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}