{"doi":"10.1189/jlb.0811402","title":"Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation","abstract":"<jats:title>ABSTRACT</jats:title><jats:p>Chemoattractants are pivotal mediators of host defense, orchestrating the recruitment of immune cells into sites of infection and inflammation. Chemoattractants display vast chemical diversity and include bioactive lipids, proteolytic fragments of serum proteins, and chemokines (chemotactic cytokines). All chemoattractants induce chemotaxis by activating seven-transmembrane-spanning GPCRs expressed on immune cells, establishing the concept that all chemoattractants are related in function. However, although chemoattractants have overlapping functions in vitro, recent in vivo data have revealed that they function, in many cases, nonredundantly in vivo. The chemically diverse nature of chemoattractants contributes to the fine control of leukocyte trafficking in vivo, with sequential chemoattractant use guiding immune cell recruitment into inflammatory sites. Lipid mediators frequently function as initiators of leukocyte recruitment, attracting the first immune cells into tissues. These initial responding immune cells produce cytokines locally, which in turn, induce the local release of chemokines. Local chemokine production then markedly amplifies subsequent waves of leukocyte recruitment. These new discoveries establish a paradigm for leukocyte recruitment in inflammation—described as lipid-cytokine-chemokine cascades—as a driving force in the effector phase of immune responses.</jats:p>","journal":"Journal of Leukocyte Biology","year":2011,"id":619095,"datarank":0.8062917611526249,"base_score":5.375278407684165,"endowment":5.375278407684165,"self_citation_contribution":0.8062917611526249,"citation_network_contribution":0.0,"self_endowment_contribution":0.8062917611526249,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":215,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1597529,"name":"Andrew D Luster","orcid":null,"position":1,"is_corresponding":false},{"id":1597527,"name":"Christian D Sadik","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation","abstract":"<jats:title>ABSTRACT</jats:title><jats:p>Chemoattractants are pivotal mediators of host defense, orchestrating the recruitment of immune cells into sites of infection and inflammation. Chemoattractants display vast chemical diversity and include bioactive lipids, proteolytic fragments of serum proteins, and chemokines (chemotactic cytokines). All chemoattractants induce chemotaxis by activating seven-transmembrane-spanning GPCRs expressed on immune cells, establishing the concept that all chemoattractants are related in function. However, although chemoattractants have overlapping functions in vitro, recent in vivo data have revealed that they function, in many cases, nonredundantly in vivo. The chemically diverse nature of chemoattractants contributes to the fine control of leukocyte trafficking in vivo, with sequential chemoattractant use guiding immune cell recruitment into inflammatory sites. Lipid mediators frequently function as initiators of leukocyte recruitment, attracting the first immune cells into tissues. These initial responding immune cells produce cytokines locally, which in turn, induce the local release of chemokines. Local chemokine production then markedly amplifies subsequent waves of leukocyte recruitment. These new discoveries establish a paradigm for leukocyte recruitment in inflammation—described as lipid-cytokine-chemokine cascades—as a driving force in the effector phase of immune responses.</jats:p>","is_dataset_classified":null,"base_score":5.375278407684165,"endowment":5.375278407684165,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22058421","pmcid":"PMC3290425","openalex_id":"https://openalex.org/W2156477464","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"P30 AI060354","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI050892","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"","title":null},{"funder_name":"NIH","grant_id":"","title":null},{"funder_name":"Arthritis Foundation","grant_id":"","title":null}],"total_grants":6,"fwci":6.6299,"citation_percentile":0.98071851,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":24},{"year":2014,"count":23},{"year":2015,"count":14},{"year":2016,"count":21},{"year":2017,"count":14},{"year":2018,"count":19},{"year":2019,"count":13},{"year":2020,"count":12},{"year":2021,"count":21},{"year":2022,"count":14},{"year":2023,"count":16},{"year":2024,"count":9},{"year":2025,"count":5},{"year":2026,"count":5}],"oa_status":"green","license":"OUP Standard Publication Reuse","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290425","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3290425","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1189%2Fjlb.0811402","host_type":"publisher"},{"url":"https://academic.oup.com/jleukbio/article-pdf/91/2/207/49618232/jlb0207.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1189/jlb.0811402","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22058421","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3290425","host_type":"repository"},{"url":"https://jlb.onlinelibrary.wiley.com/doi/pdfdirect/10.1189/jlb.0811402","host_type":""},{"url":"https://dx.doi.org/10.1189/jlb.0811402","host_type":""}],"fields_of_study":["Chemokine receptors and signaling","Immune Response and Inflammation","Receptor Mechanisms and Signaling","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Arthritis, Experimental","Asthma","Chemotactic Factors","Chemotaxis, Leukocyte","Gene Expression Regulation","Humans","Inflammation","Leukocytes","Leukotriene B4","Lipids","Neutrophils","Signal Transduction","Cytokines","Receptors, Leukotriene B4","Th2 Cells","Inflammation Mediators","Chemokines","Receptors, G-Protein-Coupled","Mice"],"keywords":["Chemokine","Chemotaxis","Biology","Immune system","Inflammation","CCL18","Cell biology","Cytokine","Immunology","CXCL14","Leukocyte Trafficking","Chemokine receptor","Receptor","Biochemistry","Chemotactic Factors","Neutrophils","Receptors, Leukotriene B4","Arthritis, Experimental","Leukotriene B4","Lipids","Asthma","Receptors, G-Protein-Coupled","Chemotaxis, Leukocyte","Mice","Th2 Cells","Gene Expression Regulation","Leukocytes","Animals","Cytokines","Humans","Chemokines","Inflammation Mediators","Signal Transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T05:59:48.228424Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}