{"doi":"10.1189/jlb.0602272","title":"Actin cytoskeletal dynamics in T lymphocyte activation and migration","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Dynamic rearrangements of the actin cytoskeleton are crucial for the function of numerous cellular elements including T lymphocytes. They are required for migration of T lymphocytes through the body to scan for the presence of antigens, as well as for the formation and stabilization of the immunological synapse at the interface between antigen-presenting cells and T lymphocytes. Supramolecular activation clusters within the immunological synapse play an important role for the initiation of T cell responses and for the execution of T cell effector functions. In addition to the T cell receptor/CD3 induced actin nucleation via Wasp/Arp2/3-activation, signals through accessory receptors of the T cell (i.e., costimulation) regulate actin cytoskeletal dynamics. In this regard, the actin-binding proteins cofilin and L-plastin represent prominent candidates linking accessory receptor stimulation to the rearrangement of the actin cytoskeleton. Cofilin enhances actin polymerization via its actin-severing activity, and as a long-lasting effect, cofilin generates novel actin monomers through F-actin depolymerization. L-plastin stabilizes acin filament structures by means of its actin-bundling activity.</jats:p>","journal":"Journal of Leukocyte Biology","year":2003,"id":655741,"datarank":0.7712495334753992,"base_score":5.14166355650266,"endowment":5.14166355650266,"self_citation_contribution":0.7712495334753992,"citation_network_contribution":0.0,"self_endowment_contribution":0.7712495334753992,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":170,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1711743,"name":"Sybille M Eibert","orcid":null,"position":1,"is_corresponding":false},{"id":1711744,"name":"Martin Klemke","orcid":null,"position":2,"is_corresponding":false},{"id":1711745,"name":"Guido H Wabnitz","orcid":null,"position":3,"is_corresponding":false},{"id":1711742,"name":"Yvonne Samstag","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Actin cytoskeletal dynamics in T lymphocyte activation and migration","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Dynamic rearrangements of the actin cytoskeleton are crucial for the function of numerous cellular elements including T lymphocytes. They are required for migration of T lymphocytes through the body to scan for the presence of antigens, as well as for the formation and stabilization of the immunological synapse at the interface between antigen-presenting cells and T lymphocytes. Supramolecular activation clusters within the immunological synapse play an important role for the initiation of T cell responses and for the execution of T cell effector functions. In addition to the T cell receptor/CD3 induced actin nucleation via Wasp/Arp2/3-activation, signals through accessory receptors of the T cell (i.e., costimulation) regulate actin cytoskeletal dynamics. In this regard, the actin-binding proteins cofilin and L-plastin represent prominent candidates linking accessory receptor stimulation to the rearrangement of the actin cytoskeleton. Cofilin enhances actin polymerization via its actin-severing activity, and as a long-lasting effect, cofilin generates novel actin monomers through F-actin depolymerization. L-plastin stabilizes acin filament structures by means of its actin-bundling activity.</jats:p>","is_dataset_classified":null,"base_score":5.14166355650266,"endowment":5.14166355650266,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12525560","pmcid":null,"openalex_id":"https://openalex.org/W2124497742","authors":[],"funders":[],"total_grants":0,"fwci":2.9919,"citation_percentile":0.92097737,"influential_citations":7,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":11},{"year":2014,"count":7},{"year":2015,"count":10},{"year":2016,"count":11},{"year":2017,"count":4},{"year":2018,"count":10},{"year":2019,"count":7},{"year":2020,"count":5},{"year":2021,"count":5},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/jleukbio/article-pdf/73/1/30/49671812/jlb0030.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1189/jlb.0602272","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12525560","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.312.2713","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Cellular Mechanics and Interactions","Cell Adhesion Molecules Research","Biology","Medicine","Actins","Animals","Cell Polarity","Chemotaxis, Leukocyte","Cytoskeleton","Humans","Lymphocyte Activation","Signal Transduction","T-Lymphocytes"],"mesh_terms":["Actins","Animals","Chemotaxis, Leukocyte","Cytoskeleton","Humans","Lymphocyte Activation","T-Lymphocytes","Signal Transduction","Cell Polarity"],"keywords":["Cofilin","Actin remodeling of neurons","Cell biology","Immunological synapse","Actin remodeling","Biology","MDia1","Cytoskeleton","Profilin","Actin","Actin cytoskeleton","Actin-binding protein","T-cell receptor","T cell","Cell","Immunology","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T18:49:53.331789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}