{"doi":"10.1189/jlb.0308206","title":"Regulation of MHC II and CD1 antigen presentation: from ubiquity to security","abstract":"<jats:title>Abstract</jats:title><jats:p>MHC class II and CD1-mediated antigen presentation on various APCs [B cells, monocytes, and dendritic cells (DC)] are subject to at least three distinct levels of regulation. The first one concerns the expression and structure of the antigen-presenting molecules; the second is based on the extracellular environment and signals of danger detected. However, a third level of regulation, which has been largely overlooked, is determined by lateral associations between antigen-presenting molecules and other proteins, their localization in specialized microdomains within the plasma membrane, and their trafficking pathways. This review focuses on features common to MHC II and CD1 molecules in their ability to activate specific T lymphocytes with the objective of addressing one basic question: What are the mechanisms regulating antigen presentation by MHC II and CD1 molecules within the same cell? Recent studies in immature DC, where MHC II and CD1 are coexpressed, suggest that the invariant chain (Ii) regulates antigen presentation by either protein. Ii could therefore favor MHC II or CD1 antigen presentation and thereby discriminate between antigens.</jats:p>","journal":"Journal of Leukocyte Biology","year":2009,"id":622657,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1608900,"name":"Ivan Sloma","orcid":null,"position":1,"is_corresponding":false},{"id":1203177,"name":"Dominique Charron","orcid":"0000-0002-3029-2169","position":2,"is_corresponding":false},{"id":564386,"name":"Nuala Mooney","orcid":"0000-0002-3516-6882","position":3,"is_corresponding":false},{"id":1608899,"name":"Catherine Gelin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Regulation of MHC II and CD1 antigen presentation: from ubiquity to security","abstract":"<jats:title>Abstract</jats:title><jats:p>MHC class II and CD1-mediated antigen presentation on various APCs [B cells, monocytes, and dendritic cells (DC)] are subject to at least three distinct levels of regulation. The first one concerns the expression and structure of the antigen-presenting molecules; the second is based on the extracellular environment and signals of danger detected. However, a third level of regulation, which has been largely overlooked, is determined by lateral associations between antigen-presenting molecules and other proteins, their localization in specialized microdomains within the plasma membrane, and their trafficking pathways. This review focuses on features common to MHC II and CD1 molecules in their ability to activate specific T lymphocytes with the objective of addressing one basic question: What are the mechanisms regulating antigen presentation by MHC II and CD1 molecules within the same cell? Recent studies in immature DC, where MHC II and CD1 are coexpressed, suggest that the invariant chain (Ii) regulates antigen presentation by either protein. Ii could therefore favor MHC II or CD1 antigen presentation and thereby discriminate between antigens.</jats:p>","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18809734","pmcid":null,"openalex_id":"https://openalex.org/W2045324106","authors":[],"funders":[{"funder_name":"Institut National de la Santé et de la Recherche Médicale","grant_id":"","title":null}],"total_grants":1,"fwci":2.1076,"citation_percentile":0.8707674,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2022,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/jleukbio/article-pdf/85/2/215/49611262/jlb0215.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1189/jlb.0308206","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18809734","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.627.5991","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Immunotherapy and Immune Responses","Animals","Antigen Presentation","Antigens, CD1","Extracellular Space","Histocompatibility Antigens Class I","Histocompatibility Antigens Class II","Humans","Membrane Microdomains"],"mesh_terms":["Animals","Histocompatibility Antigens Class II","Extracellular Space","Humans","Histocompatibility Antigens Class I","Antigen Presentation","Antigens, CD1","Membrane Microdomains"],"keywords":["CD1","Antigen presentation","Biology","Antigen","Antigen processing","MHC restriction","MHC class II","Cell biology","MHC class I","Major histocompatibility complex","Antigen-presenting cell","Cross-presentation","T cell","Immunology","Immune system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T20:29:51.427893Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}