{"doi":"10.1186/scrt205","title":"Therapeutic effects of mesenchymal stem cells on renal ischemia–reperfusion injury: a matter of genetic transfer?","abstract":null,"journal":"Stem Cell Research & Therapy","year":2013,"id":679370,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":215767,"name":"Benedetta Bussolati","orcid":"0000-0002-3663-5134","position":1,"is_corresponding":false},{"id":68148,"name":"Stefania Bruno","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Therapeutic effects of mesenchymal stem cells on renal ischemia–reperfusion injury: a matter of genetic transfer?","abstract":"Accumulating evidence indicates that the protective effect of mesenchymal stem cells in models of tissue injury is related to the endocrine/pcrine release of factors. The delivery of growth factors, cytokines, prostaglandins, enzymes or extracellular vesicles from mesenchymal stem cells to target cells may induce cell reprogramming and de novo expression of factors involved in tissue proliferation and repair. A recent paper showed that Wharton jelly-derived mesenchymal stem cells interact with injured renal tubular epithelial cells, inducing the expression of native and foreign hepatocyte growth factor necessary for renal repair and fibrogenesis inhibition. The genetic exchange between resident and mesenchymal stem cells, probably mediated through microvesicles, therefore appears instrumental in mesenchymal stem cell therapeutic effects.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23731907","pmcid":"PMC3706966","openalex_id":"https://openalex.org/W2149323967","authors":[],"funders":[],"total_grants":0,"fwci":0.7368,"citation_percentile":0.71290469,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":3},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2022,"count":1},{"year":2023,"count":1}],"oa_status":"gold","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt205","host_type":"journal"},{"url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt205","host_type":"GOLD"},{"url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt205","host_type":"publisher"},{"url":"https://link.springer.com/content/pdf/10.1186/scrt205.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1186/scrt205/fulltext.html","host_type":"publisher"},{"url":"https://doi.org/10.1186/scrt205","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23731907","host_type":"repository"},{"url":"http://hdl.handle.net/2318/1633402","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3706966","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3706966","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3706966","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3706966?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Mesenchymal stem cell research","Extracellular vesicles in disease","MicroRNA in disease regulation","Biology","Medicine","Animals","Epithelial Cells","Hepatocyte Growth Factor","Humans","Male","Mesenchymal Stem Cells","Wharton Jelly"],"mesh_terms":["Animals","Epithelial Cells","Humans","Male","Hepatocyte Growth Factor","Mesenchymal Stem Cells","Wharton Jelly"],"keywords":["Mesenchymal stem cell","Stem cell","Cell biology","Microvesicles","Hepatocyte growth factor","Renal stem cell","Amniotic stem cells","Stem cell transplantation for articular cartilage repair","Clinical uses of mesenchymal stem cells","Biology","Paracrine signalling","Adult stem cell","Endothelial stem cell","Cancer research","Immunology","Progenitor cell","microRNA","Biochemistry","In vitro"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T13:02:24.678864Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}