{"doi":"10.1186/s40902-021-00326-2","title":"The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells","abstract":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Method</jats:title>\n                <jats:p>In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (<jats:italic>p</jats:italic> &lt; 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (<jats:italic>p</jats:italic> &lt; 0.05; 10 and 100 μM at 24 h).</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusion</jats:title>\n                <jats:p>4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.</jats:p>\n              </jats:sec>","journal":"Maxillofacial Plastic and Reconstructive Surgery","year":2021,"id":14776,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115302,"name":"Jun-Ho Chang","orcid":null,"position":1,"is_corresponding":false},{"id":115303,"name":"Dae-Won Kim","orcid":null,"position":2,"is_corresponding":false},{"id":115304,"name":"Seong-Gon Kim","orcid":"0000-0001-5088-2732","position":3,"is_corresponding":false},{"id":115305,"name":"Tae-Woo Kim","orcid":null,"position":4,"is_corresponding":false},{"id":115301,"name":"In-Song Lee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-06-01T14:28:49.533667Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}