{"doi":"10.1186/s40814-024-01580-7","title":"Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment","abstract":null,"journal":"Pilot and Feasibility Studies","year":2025,"id":594114,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":784683,"name":"Alexander R. Lucas","orcid":"0000-0001-7318-3387","position":1,"is_corresponding":false},{"id":602083,"name":"Shannon L. Mihalko","orcid":"0000-0003-1270-2520","position":2,"is_corresponding":false},{"id":648156,"name":"Peter H. Brubaker","orcid":"0000-0003-0918-4056","position":3,"is_corresponding":false},{"id":1520709,"name":"Alexandra Marshall","orcid":null,"position":4,"is_corresponding":false},{"id":1520711,"name":"Brianna Leitzelar","orcid":null,"position":5,"is_corresponding":false},{"id":1281850,"name":"Brianna R. Wolle","orcid":null,"position":6,"is_corresponding":false},{"id":1520714,"name":"Samuel Norton","orcid":null,"position":7,"is_corresponding":false},{"id":304976,"name":"R. 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Costa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment","abstract":"To determine the feasibility, acceptability, and preliminary efficacy of a 6-month tailored non-linear progressive physical activity intervention (PAI) for lymphoma patients undergoing chemotherapy. Patients newly diagnosed with lymphoma (non-Hodgkin (NHL) or Hodgkin (HL)) were randomized into the PAI or healthy living intervention (HLI) control (2:1). Feasibility was assessed by examining accrual, adherence, and retention rates. Participants completed assessments of exercise capacity (VO 2 peak and 6-min walk distance (6MWD)), objective and self-reported levels of physical activity, MRI-derived cardiovascular functioning (Left Ventricular Ejection Fraction [LVEF], stroke volume, and cardiac output), and self-reported health-related and disease-specific quality of life and self-efficacy for exercise at baseline, 3, and 6 months. One hundred and forty-five individuals were screened with 23 of 84 eligible patients agreeing to participate (27%). Three participants withdrew before baseline testing. Out of the 20 participants randomized to the PAI ( n = 13) and HLI groups ( n = 7), 18 completed the intervention resulting in an overall retention rate of 78%. The adherence rates to the PAI and HLI were 85% and 87%, respectively. One non-serious adverse event was registered. VO 2 peak ranged from 15.5–28.0 ml/kg/min at baseline and participants in both groups improved by 6 months. Physical activity levels and cardiovascular function were reduced prior to treatment but did not deteriorate further. Implementing a tailored PAI in adults with lymphoma during active treatment is feasible, was well received by participants and shows preliminary efficacy for limiting a decline in function during treatment. Potential Implications for Cancer Survivors: Physical activity may be beneficial for improving exercise capacity and health-related quality of life in patients undergoing chemotherapy. #NCT01719562 ClinicalTrials.gov. 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