{"doi":"10.1186/s12974-024-03295-1","title":"IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production","abstract":"BACKGROUND: Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased serum levels of IL-37. However, it is unknown whether IL-37 has an inhibitory effect on ongoing autoimmune neuroinflammation, thus offering a potential MS therapy. AIM: Here, we examined the effect of IL-37 in an experimental autoimmune encephalomyelitis (EAE) model after disease onset to determine if it was protective. FINDINGS: IL-37-treated mice developed a less severe disease than control mice, with reduced demyelination as determined by increased expression of myelin basic protein. IL-37 suppressed inflammation by decreasing infiltration of CD4 + T cells into the CNS and increasing the frequency of regulatory T cells, while IL-10 expression by CD4 + T cells decreased over time in the CNS. CONCLUSION: Our findings confirm the immunomodulatory role of IL-37 in CNS inflammation during ongoing disease, thus indicating the potential of IL-37 as an inhibitory reagent for MS therapy.","journal":"Journal of Neuroinflammation","year":2024,"id":447895,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1246168,"name":"Hamed Naziri","orcid":"0000-0001-6290-8944","position":1,"is_corresponding":false},{"id":884884,"name":"Gholamreza Azizi","orcid":"0000-0001-5658-2511","position":2,"is_corresponding":false},{"id":281023,"name":"Bogoljub Ćirić","orcid":"0000-0001-5361-7635","position":3,"is_corresponding":false},{"id":1266021,"name":"Mozhde Askari","orcid":"0000-0003-3055-3389","position":4,"is_corresponding":false},{"id":1266022,"name":"Amir Moghadam Ahmadi","orcid":"0000-0003-2756-1265","position":5,"is_corresponding":false},{"id":371176,"name":"Jaya Aseervatham","orcid":"0000-0002-0160-0951","position":6,"is_corresponding":false},{"id":1266506,"name":"Guang-Xian Zhang","orcid":null,"position":7,"is_corresponding":false},{"id":281024,"name":"Abdolmohamad Rostami","orcid":"0000-0003-0716-2726","position":8,"is_corresponding":false},{"id":1246169,"name":"Reza Yazdani","orcid":"0000-0002-3760-4137","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:02:03.354708Z","pmid":"39563375","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}