{"doi":"10.1186/s12967-024-05205-8","title":"Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis","abstract":"Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (sIL-6-Rα) in the peritoneal cavity of patients with PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides a comprehensive overview of the current understanding of the potential role of IL-6 in the development and progression of PC. We discuss mechansims by which the IL-6 pathway may contribute to peritoneal tumor dissemination, mesothelial adhesion and invasion, stromal invasion and proliferation, and immune response modulation. Finally, we review the prospects for targeting the IL-6 pathway in the treatment of PC, focusing on common sites of origin, including ovarian, gastric, pancreatic, colorectal and appendiceal cancer, and mesothelioma.","journal":"Journal of Translational Medicine","year":2024,"id":431085,"datarank":0.614689728834031,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.16532988780093222,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.16532988780093222,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":16,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1235399,"name":"Christopher Sherry","orcid":null,"position":1,"is_corresponding":false},{"id":1235400,"name":"Jenna Zimmerman","orcid":null,"position":2,"is_corresponding":false},{"id":1234898,"name":"Hyun Park","orcid":"0000-0002-7825-9165","position":3,"is_corresponding":false},{"id":1235401,"name":"Catherine Lewis","orcid":null,"position":4,"is_corresponding":false},{"id":279579,"name":"Albert D. Donnenberg","orcid":"0000-0002-6723-3330","position":5,"is_corresponding":false},{"id":573637,"name":"Ali H. Zaidi","orcid":"0000-0002-5463-2252","position":6,"is_corresponding":false},{"id":731607,"name":"Yong Fan","orcid":"0000-0002-0258-4826","position":7,"is_corresponding":false},{"id":592268,"name":"Kunhong Xiao","orcid":"0000-0002-1069-1226","position":8,"is_corresponding":false},{"id":242170,"name":"David L. Bartlett","orcid":"0000-0003-3099-2613","position":9,"is_corresponding":false},{"id":279578,"name":"Vera S. Donnenberg","orcid":"0000-0003-3519-1938","position":10,"is_corresponding":false},{"id":71346,"name":"Patrick Wagner","orcid":"0000-0001-8105-653X","position":11,"is_corresponding":false},{"id":280997,"name":"Neda Dadgar","orcid":"0000-0003-3220-7148","position":0,"is_corresponding":true}],"reference_count":278,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:59:25.642507Z","pmid":"38689325","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}