{"doi":"10.1186/s12967-024-05195-7","title":"Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine","abstract":"BACKGROUND: Bacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies have focused on gram-negative bacterial outer membrane vesicles (OMVs) as a novel cancer immunotherapy strategy due to its intrinsic properties as a versatile carrier. METHOD: Here, we developed an Human Papillomavirus (HPV)-associated E7 antigen displaying Salmonella-derived OMV vaccine, utilizing a Poly(L-arginine) cell penetrating peptide (CPP) to enhance HPV16 E7 (aa49-67) H-2 Db and OMV affinity, termed SOMV-9RE7. RESULTS: Due to OMV's intrinsic immunogenic properties, SOMV-9RE7 effectively activates adaptive immunity through antigen-presenting cell uptake and antigen cross-presentation. Vaccination of engineered OMVs shows immediate tumor suppression and recruitment of infiltrating tumor-reactive immune cells. CONCLUSION: The simplicity of the arginine coating strategy boasts the versatility of immuno-stimulating OMVs that can be broadly implemented to personalized bacterial immunotherapeutic applications.","journal":"Journal of Translational Medicine","year":2024,"id":436566,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":950009,"name":"Chao‐Cheng Chen","orcid":"0000-0003-2685-6766","position":1,"is_corresponding":false},{"id":1122421,"name":"Ming‐Hung Hu","orcid":"0000-0002-9923-0281","position":2,"is_corresponding":false},{"id":1074998,"name":"Michelle Y. Cheng","orcid":"0009-0009-3158-8226","position":3,"is_corresponding":false},{"id":899678,"name":"Hsin-Fang Tu","orcid":"0009-0008-9048-493X","position":4,"is_corresponding":false},{"id":42015,"name":"Ya-Chea Tsai","orcid":null,"position":5,"is_corresponding":false},{"id":577280,"name":"Jr-Ming Yang","orcid":"0000-0002-6296-8987","position":6,"is_corresponding":false},{"id":1245430,"name":"Twin-Ling Wu","orcid":null,"position":7,"is_corresponding":false},{"id":292073,"name":"Chuan‐Hsiang Huang","orcid":"0000-0001-9993-8004","position":8,"is_corresponding":false},{"id":42022,"name":"Chien‐Fu Hung","orcid":"0000-0001-9170-7797","position":9,"is_corresponding":false},{"id":899679,"name":"Suyang Wang","orcid":"0009-0002-9139-1723","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:00:16.989773Z","pmid":"38649894","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}