{"doi":"10.1186/s12931-024-02701-9","title":"Intra-breath changes in respiratory mechanics are sensitive to history of respiratory illness in preschool children: the SEPAGES cohort","abstract":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>Intra-breath oscillometry has been proposed as a sensitive means of detecting airway obstruction in young children. We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both standard and intra-breath oscillometry in 3 year old children.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory problems were assessed by questionnaires in 384 population-based children. Association of respiratory history with standard and intra-breath oscillometry parameters, including resistance at 7 Hz (R<jats:sub>7</jats:sub>), frequency-dependence of resistance (R<jats:sub>7 − 19</jats:sub>), reactance at 7 Hz (X<jats:sub>7</jats:sub>), area of the reactance curve (AX), end-inspiratory and end-expiratory R (R<jats:sub>eI</jats:sub>, R<jats:sub>eE</jats:sub>) and X (X<jats:sub>eI</jats:sub>, X<jats:sub>eE</jats:sub>), and volume-dependence of resistance (ΔR = R<jats:sub>eE</jats:sub>-R<jats:sub>eI</jats:sub>) was estimated by linear regression adjusted on confounders.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>Among the 320 children who accepted the oscillometry test, 281 (88%) performed 3 technically acceptable and reproducible standard oscillometry measurements and 251 children also performed one intra-breath oscillometry measurement. Asthma was associated with higher R<jats:sub>eI</jats:sub>, R<jats:sub>eE</jats:sub>, ΔR and R<jats:sub>7</jats:sub> and wheezing was associated with higher ΔR. Bronchiolitis was associated with higher R<jats:sub>7</jats:sub> and AX and lower X<jats:sub>eI</jats:sub> and bronchitis with higher R<jats:sub>eI</jats:sub>. No statistically significant association was observed for hospitalisation.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusions</jats:title>\n                <jats:p>Our findings confirm the good success rate of oscillometry in 3-year-old children and indicate an association between a history of early-life wheezing and lower respiratory tract illness and lower lung function as assessed by both standard and intra-breath oscillometry. Our study supports the relevance of using intra-breath oscillometry parameters as sensitive outcome measures in preschool children in epidemiological cohorts.</jats:p>\n              </jats:sec>","journal":"Respiratory Research","year":2024,"id":642529,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1671317,"name":"Anne Boudier","orcid":null,"position":1,"is_corresponding":false},{"id":361717,"name":"Sarah Lyon-Caen","orcid":"0000-0002-7229-3135","position":2,"is_corresponding":false},{"id":1671318,"name":"Joane Quentin","orcid":null,"position":3,"is_corresponding":false},{"id":1671319,"name":"Yoann Gioria","orcid":null,"position":4,"is_corresponding":false},{"id":1110661,"name":"Zoltán Hantos","orcid":"0000-0002-5696-7750","position":5,"is_corresponding":false},{"id":237213,"name":"Rémy Slama","orcid":"0000-0002-8980-8529","position":6,"is_corresponding":false},{"id":361720,"name":"Isabelle Pin","orcid":"0000-0002-7529-6999","position":7,"is_corresponding":false},{"id":1671322,"name":"Sam Bayat","orcid":null,"position":8,"is_corresponding":false},{"id":237203,"name":"Valérie Siroux","orcid":"0000-0001-7329-7237","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Intra-breath changes in respiratory mechanics are sensitive to history of respiratory illness in preschool children: the SEPAGES cohort","abstract":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>Intra-breath oscillometry has been proposed as a sensitive means of detecting airway obstruction in young children. We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both standard and intra-breath oscillometry in 3 year old children.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory problems were assessed by questionnaires in 384 population-based children. Association of respiratory history with standard and intra-breath oscillometry parameters, including resistance at 7 Hz (R<jats:sub>7</jats:sub>), frequency-dependence of resistance (R<jats:sub>7 − 19</jats:sub>), reactance at 7 Hz (X<jats:sub>7</jats:sub>), area of the reactance curve (AX), end-inspiratory and end-expiratory R (R<jats:sub>eI</jats:sub>, R<jats:sub>eE</jats:sub>) and X (X<jats:sub>eI</jats:sub>, X<jats:sub>eE</jats:sub>), and volume-dependence of resistance (ΔR = R<jats:sub>eE</jats:sub>-R<jats:sub>eI</jats:sub>) was estimated by linear regression adjusted on confounders.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>Among the 320 children who accepted the oscillometry test, 281 (88%) performed 3 technically acceptable and reproducible standard oscillometry measurements and 251 children also performed one intra-breath oscillometry measurement. Asthma was associated with higher R<jats:sub>eI</jats:sub>, R<jats:sub>eE</jats:sub>, ΔR and R<jats:sub>7</jats:sub> and wheezing was associated with higher ΔR. Bronchiolitis was associated with higher R<jats:sub>7</jats:sub> and AX and lower X<jats:sub>eI</jats:sub> and bronchitis with higher R<jats:sub>eI</jats:sub>. No statistically significant association was observed for hospitalisation.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusions</jats:title>\n                <jats:p>Our findings confirm the good success rate of oscillometry in 3-year-old children and indicate an association between a history of early-life wheezing and lower respiratory tract illness and lower lung function as assessed by both standard and intra-breath oscillometry. Our study supports the relevance of using intra-breath oscillometry parameters as sensitive outcome measures in preschool children in epidemiological cohorts.</jats:p>\n              </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38402379","pmcid":"PMC10893684","openalex_id":null,"authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"311765","title":"Environmentally-induced Developmental Origins of Health and Disease"},{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-12-PDOC-0029","title":"Pregnancy, Air Pollution, Epigenetics, and Respiratory health"},{"funder_name":"European Commission","grant_id":"874583","title":"Advancing Tools for Human Early Lifecourse Exposome Research and Translation"},{"funder_name":"European Commission","grant_id":"825712","title":"An integrative strategy of testing systems for identification of EDs related to metabolic disorders"},{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-14-CE21-0007","title":"A Longitudinal Analysis of Effects of Early Life Exposure to Phenols on Health in Humans"},{"funder_name":"European Commission","grant_id":"308333","title":"The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe"}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"CC BY","oa_locations":[{"url":"https://link.springer.com/content/pdf/10.1186/s12931-024-02701-9.pdf","host_type":"publisher"},{"url":"https://link.springer.com/article/10.1186/s12931-024-02701-9/fulltext.html","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC10893684","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10893684?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1186/s12931-024-02701-9","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/38402379","host_type":""},{"url":"http://dx.doi.org/10.1186/s12931-024-02701-9","host_type":""},{"url":"https://doaj.org/article/713e5df0f9cf442d817d7e638545ea79","host_type":""},{"url":"https://hal.science/hal-04521370v1","host_type":""},{"url":"https://hal.science/hal-04521370v1/document","host_type":""},{"url":"http://publicatio.bibl.u-szeged.hu/35898/1/SirouxRespRes.pdf","host_type":""},{"url":"https://doi.org/https://doi.org/10.1186/s12931-024-02701-9","host_type":""}],"fields_of_study":["03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Respiratory System","Humans","Asthma","Bronchitis","Bronchiolitis","Respiratory Sounds","Spirometry","Respiratory Mechanics","Child, Preschool"],"keywords":["Asthma","Preschool children","epidemiology","Forced Oscillation Technique","Respiratory Resistance","Respiratory Reactance","Respiratory System","610","910","[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract","618","Diseases of the respiratory system","[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics","Humans","03.02. 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