{"doi":"10.1186/s12929-024-01093-8","title":"Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis","abstract":"ROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of the most abundant. If left unrepaired, 8-oxoGua may pair with A instead of C, leading to a mutation of G: C to T: A during DNA replication. 8-Oxoguanine DNA glycosylase 1 (OGG1) is a tailored repair enzyme that recognizes 8-oxoGua in DNA duplex and initiates the base excision repair (BER) pathway to remove the lesion and ensure the fidelity of the genome. The accumulation of genomic 8-oxoGua and the dysfunction of OGG1 is readily linked to mutagenesis, and subsequently aging-related diseases and tumorigenesis; however, the direct experimental evidence has long been lacking. Recently, a series of studies have shown that guanine oxidation in the genome has a conservative bias, with the tendency to occur in the regulatory regions, thus, 8-oxoGua is not only a lesion to be repaired, but also an epigenetic modification. In this regard, OGG1 is a specific reader of this base modification. Substrate recognition and/or excision by OGG1 can cause DNA conformation changes, affect chromatin modifications, thereby modulating the transcription of genes involved in a variety of cellular processes, including inflammation, cell proliferation, differentiation, and apoptosis. Thus, in addition to the potential mutagenicity, 8-oxoGua may contribute to tumor development and progression through the altered gene expression stemming from its epigenetic effects.","journal":"Journal of Biomedical Science","year":2025,"id":509258,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1363995,"name":"Chunshuang Li","orcid":null,"position":1,"is_corresponding":false},{"id":1363141,"name":"Jinling Han","orcid":"0009-0003-0437-3349","position":2,"is_corresponding":false},{"id":1107687,"name":"Yaoyao Xue","orcid":"0000-0003-2137-6181","position":3,"is_corresponding":false},{"id":1107688,"name":"Xu Zheng","orcid":"0000-0001-5523-7177","position":4,"is_corresponding":false},{"id":1363142,"name":"Ruoxi Wang","orcid":"0000-0002-1992-6853","position":5,"is_corresponding":false},{"id":988543,"name":"Zsolt Radák","orcid":"0000-0003-1297-6804","position":6,"is_corresponding":false},{"id":336348,"name":"Yusaku Nakabeppu","orcid":"0000-0002-6739-242X","position":7,"is_corresponding":false},{"id":724067,"name":"István Boldogh","orcid":"0000-0002-0088-1130","position":8,"is_corresponding":false},{"id":826388,"name":"Xueqing Ba","orcid":"0000-0002-1075-5496","position":9,"is_corresponding":false},{"id":1363140,"name":"Jing Wang","orcid":"0000-0001-7863-1441","position":0,"is_corresponding":true}],"reference_count":116,"raw_metadata":null,"created_at":"2026-07-19T02:47:24.513904Z","pmid":"39741341","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}