{"doi":"10.1186/gb-2011-12-4-r41","title":"GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers","abstract":"We describe methods with enhanced power and specificity to identify genes targeted by somatic copy-number alterations (SCNAs) that drive cancer growth. By separating SCNA profiles into underlying arm-level and focal alterations, we improve the estimation of background rates for each category. We additionally describe a probabilistic method for defining the boundaries of selected-for SCNA regions with user-defined confidence. Here we detail this revised computational approach, GISTIC2.0, and validate its performance in real and simulated datasets.","journal":"Genome Biology","year":2011,"id":11121,"datarank":1.2377495885408385,"base_score":8.251663923605589,"endowment":8.251663923605589,"self_citation_contribution":1.2377495885408385,"citation_network_contribution":0.0,"self_endowment_contribution":1.2377495885408385,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3833,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0419,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2011-04-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":13157,"name":"Steven E. Schumacher","orcid":"0000-0002-6819-5647","position":1,"is_corresponding":false},{"id":40421,"name":"Barbara Hill","orcid":null,"position":2,"is_corresponding":false},{"id":1398,"name":"Rameen Beroukhim","orcid":"0000-0001-6303-3609","position":4,"is_corresponding":false},{"id":1058,"name":"Gad Getz","orcid":"0000-0002-0936-0753","position":5,"is_corresponding":false},{"id":13136,"name":"Patrick D. McGillivray","orcid":"0000-0002-8156-1058","position":6,"is_corresponding":false},{"id":1802,"name":"Craig H. Mermel","orcid":"0000-0002-0816-3395","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}