{"doi":"10.1186/alzrt211","title":"The role of APP and BACE1 trafficking in APP processing and amyloid-β generation","abstract":null,"journal":"Alzheimer's Research & Therapy","year":2013,"id":589460,"datarank":5.269187691738288,"base_score":5.356586274672012,"endowment":5.356586274672012,"self_citation_contribution":0.8034879412008019,"citation_network_contribution":4.465699750537485,"self_endowment_contribution":0.8034879412008019,"citer_contribution":4.465699750537485,"corpus_percentile":null,"corpus_rank":null,"citation_count":211,"citer_count":199,"citers_with_citation_signal":167,"citers_with_endowment":167,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371197,"name":"Weihong Song","orcid":"0000-0001-9928-889X","position":1,"is_corresponding":false},{"id":512101,"name":"Xiaojie Zhang","orcid":"0000-0002-8204-4845","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of APP and BACE1 trafficking in APP processing and amyloid-β generation","abstract":"Neuritic plaques in the brain are a major neuropathological hallmark of Alzheimer's disease. They are formed by the deposition and aggregation of extracellular amyloid-β protein (Aβ). Aβ is derived from the sequential cleavage of amyloid-β precursor protein (APP) by β-secretase and γ-secretase. β-Site APP cleaving enzyme 1 (BACE1) functions as the primary, if not sole, β-secretase in vivo and is essential for Aβ production. Regulation of APP processing is a major focus of research into AD pathogenesis. The trafficking systems of APP and its cleavage enzymes are complex. Transporting APP and secretases into the same subcellular organelles facilitates their interaction and favors APP processing. The role of APP and BACE1 trafficking in the amyloidgenic pathway and the underlying mechanisms for Aβ production are discussed in this review. In addition, the distinct mechanisms of amino- and carboxy-terminal Aβ generation are reviewed.","is_dataset_classified":null,"base_score":5.356586274672012,"endowment":5.356586274672012,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24103387","pmcid":"PMC3978418","openalex_id":"https://openalex.org/W2139018071","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":3.1575,"citation_percentile":0.92258398,"influential_citations":0,"citation_trend":[{"year":2014,"count":3},{"year":2015,"count":10},{"year":2016,"count":6},{"year":2017,"count":14},{"year":2018,"count":15},{"year":2019,"count":8},{"year":2020,"count":12},{"year":2021,"count":5},{"year":2022,"count":25},{"year":2023,"count":26},{"year":2024,"count":37},{"year":2025,"count":27},{"year":2026,"count":23}],"oa_status":"gold","license":"CC BY","oa_locations":[{"url":"https://alzres.biomedcentral.com/counter/pdf/10.1186/alzrt211","host_type":"journal"},{"url":"https://alzres.biomedcentral.com/counter/pdf/10.1186/alzrt211","host_type":"publisher"},{"url":"https://doi.org/10.1186/alzrt211","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24103387","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3978418","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3978418","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3978418?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1186/alzrt211","host_type":""},{"url":"https://dx.doi.org/10.1186/alzrt211","host_type":""}],"fields_of_study":["Alzheimer's disease research and treatments","Prion Diseases and Protein Misfolding","Cholinesterase and Neurodegenerative Diseases","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Amyloid precursor protein","Senile plaques","Amyloid precursor protein secretase","Alpha secretase","P3 peptide","Cell biology","Biochemistry of Alzheimer's disease","BACE1-AS","Extracellular","Amyloid (mycology)","Cleavage (geology)","Alzheimer's disease","Chemistry","Neuroscience","Biology","Disease","Medicine","Pathology","Review"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.23583691.v1","title":"Additional file 1 of Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.23583691","title":"Additional file 1 of Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.23583694.v1","title":"Additional file 2 of Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.23583694","title":"Additional file 2 of Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26584101.v1","title":"Additional file 2 of PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26584101","title":"Additional file 2 of PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-23T18:46:42.326051Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}