{"doi":"10.1186/1752-0509-5-136","title":"MicroRNAs coordinately regulate protein complexes","abstract":"<h4>Background</h4>In animals, microRNAs (miRNAs) regulate the protein synthesis of their target messenger RNAs (mRNAs) by either translational repression or deadenylation. miRNAs are frequently found to be co-expressed in different tissues and cell types, while some form polycistronic clusters on genomes. Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.<h4>Results</h4>Here we integrated information from predicted and experimentally verified miRNA targets to characterize protein complex networks regulated by human miRNAs. We found striking evidence that individual miRNAs or co-expressed miRNAs frequently target several components of protein complexes. We experimentally verified that the miR-141-200c cluster targets different components of the CtBP/ZEB complex, suggesting a potential orchestrated regulation in epithelial to mesenchymal transition.<h4>Conclusions</h4>Our findings indicate a coordinate posttranscriptional regulation of protein complexes by miRNAs. These provide a sound basis for designing experiments to study miRNA function at a systems level.","journal":"BMC Systems Biology","year":2011,"id":4475,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0486,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2011-08-25","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":45538,"name":"Sabine Dietmann","orcid":"0000-0001-6672-8457","position":1,"is_corresponding":false},{"id":45539,"name":"Ulrike C Burk","orcid":null,"position":2,"is_corresponding":false},{"id":45540,"name":"Simone Brabletz","orcid":"0000-0003-0936-1526","position":3,"is_corresponding":false},{"id":22160,"name":"Dominik Lutter","orcid":"0000-0002-8800-0683","position":4,"is_corresponding":false},{"id":5458,"name":"Andreas Kowarsch","orcid":null,"position":5,"is_corresponding":false},{"id":75600,"name":"Klaus F.X. Mayer","orcid":null,"position":6,"is_corresponding":false},{"id":45542,"name":"Thomas Brabletz","orcid":"0000-0003-2983-9048","position":7,"is_corresponding":false},{"id":5457,"name":"Andreas Ruepp","orcid":"0000-0003-1705-3515","position":8,"is_corresponding":false},{"id":42,"name":"Fabian Joachim Theis","orcid":"0000-0002-2419-1943","position":9,"is_corresponding":false},{"id":22277,"name":"Yu Wang","orcid":"0000-0003-4635-7059","position":10,"is_corresponding":false},{"id":45543,"name":"Ulrike Burk","orcid":"0009-0006-1484-0707","position":11,"is_corresponding":false},{"id":45544,"name":"Klaus Mayer","orcid":"0000-0001-6484-1077","position":12,"is_corresponding":false},{"id":5613,"name":"Steffen Sass","orcid":"0000-0001-8939-1084","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}