{"doi":"10.1183/13993003.congress-2016.oa463","title":"LSC Abstract – Systemic and local metabolomics profiling reveals novel insights into the progression of emphysema","abstract":"COPD, the third leading cause of death worldwide, is characterized by small airway remodeling, chronic bronchitis and emphysema, which is the destruction of alveolar structures impairing the ability for gaseous exchange. Metabolomics, a rapidly expanding field, offers a powerful tool for assessing the physiological state of an individual yielding a snapshot of cellular activities closer to the phenotype. To further understand the pathological mechanisms underlying progressive emphysema we used mass spectrometry–based targeted metabolomics approaches to quantitate the lung tissue, BALF and serum metabolome during emphysema progression in the established murine elastase (PPE) model. A single oropharyngeal application of PPE (80U/kg) to B6 mice resulted in a progressive severe emphysema as demonstrated by declining lung function and increased airspace enlargement. PLS analysis revealed greater changes in the metabolome of lung tissue followed by BALF rather than serum during emphysema progression. Furthermore, we demonstrate for the first time that emphysema progression is associated with a reduction in lung specific L-carnitine (1.75 fold), a metabolite critical for energy production and protector against apoptosis. Supplementation of PPE-treated mice with L-carnitine improved lung function compared to PPE only-treated animals (Compliance 0.051±0.006 vs 0.067±0.008 ml/cmH<sub>2</sub>0, p&lt;0.01). Emphysema progression is thus associated with a reduction in the global metabolomic profile, which is compartment specific, with most changes being local to the lung tissue. Importantly, L-carnitine might represent a new significant therapeutic potential for emphysema. <i>This abstract has been presented previously at the European Respiratory Society9s Lung Science Conference in March 2016.</i>","journal":"3.2 Airway Cell Biology and Immunopathology","year":2016,"id":6598,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0538,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2016-09-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":19618,"name":"Jörg Bartel","orcid":null,"position":1,"is_corresponding":false},{"id":11467,"name":"Cornelia Prehn","orcid":"0000-0002-1274-4715","position":2,"is_corresponding":false},{"id":2337,"name":"Jan Krumsiek","orcid":"0000-0003-4734-3791","position":3,"is_corresponding":false},{"id":2342,"name":"Jerzy Adamski","orcid":"0000-0001-9259-0199","position":5,"is_corresponding":false},{"id":572,"name":"Oliver Eickelberg","orcid":"0000-0001-7170-0360","position":6,"is_corresponding":false},{"id":576,"name":"Ali Önder Yildirim","orcid":"0000-0003-1969-480X","position":7,"is_corresponding":false},{"id":529,"name":"Thomas M. Conlon","orcid":"0000-0002-4316-6612","position":8,"is_corresponding":false},{"id":42,"name":"Fabian Joachim Theis","orcid":"0000-0002-2419-1943","position":9,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}