{"doi":"10.1183/13993003.02262-2019","title":"Antinuclear antibodies and subclinical interstitial lung disease in community-dwelling adults: the MESA study","abstract":"The presence of a systemic autoimmune rheumatic disease (ARD) is a well-known risk factor for interstitial lung disease (ILD). For example, 33% of adults with rheumatoid arthritis (RA) have subclinical ILD [1]. Higher serum levels of IgM rheumatoid factor (RF), IgA RF, and anti-cyclic citrullinated peptide antibody 2 are associated with subclinical ILD in community-dwelling adults [2]. It is unknown whether this relationship between autoimmunity and subclinical ILD is limited to RA-related autoantibodies, or extends more broadly to other epitopes. High attenuation areas (HAA) and interstitial lung abnormalities (ILA) are validated quantitative and qualitative subclinical ILD phenotypes, respectively. In community-dwelling adults, greater HAA is associated with reduced forced vital capacity, reduced exercise capacity, elevated serum levels of matrix metalloproteinase-7 and interleukin-6, higher prevalence of ILA on computed tomography (CT) scans of the chest, higher all-cause mortality rate, and an increased risk of developing clinically evident ILD and ILD-specific mortality at 12-year follow-up [3, 4]. ILA has been associated with all-cause mortality in four different longitudinal cohorts [5]. The purpose of this study was to examine the association between antinuclear antibody (ANA) and both HAA and ILA in community-dwelling adults enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). Antinuclear antibodies are associated with subclinical interstitial lung disease in community-dwelling adults enrolled in the Multi-Ethnic Study of Atherosclerosis <http://bit.ly/2FIEJpS> The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at [www.mesa-nhlbi.org][1] [1]: http://www.mesa-nhlbi.org","journal":"European Respiratory Journal","year":2020,"id":108497,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9625,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":520207,"name":"John H. M. Austin","orcid":null,"position":1,"is_corresponding":false},{"id":329835,"name":"Steven M. Kawut","orcid":"0000-0001-7896-0608","position":2,"is_corresponding":false},{"id":33092,"name":"Ganesh Raghu","orcid":"0000-0001-7506-6643","position":3,"is_corresponding":false},{"id":250090,"name":"Eric A. Hoffman","orcid":"0000-0001-8456-9437","position":4,"is_corresponding":false},{"id":350033,"name":"John D. Newell","orcid":"0000-0002-7337-5001","position":5,"is_corresponding":false},{"id":519501,"name":"Jubal R. Watts","orcid":"0000-0002-9006-1637","position":6,"is_corresponding":false},{"id":520208,"name":"P. H. Nath","orcid":null,"position":7,"is_corresponding":false},{"id":519502,"name":"Sushilkumar K. Sonavane","orcid":"0000-0001-8823-7261","position":8,"is_corresponding":false},{"id":24685,"name":"R. Graham Barr","orcid":"0000-0001-8021-0072","position":9,"is_corresponding":false},{"id":314630,"name":"David J. Lederer","orcid":"0000-0001-5258-0228","position":10,"is_corresponding":false},{"id":332664,"name":"Elana J. Bernstein","orcid":"0000-0001-5560-6390","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-18T23:12:43.081337Z","pmid":"31980490","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}