{"doi":"10.1183/13993003.02171-2023","title":"CD94<sup>+</sup>natural killer cells potentiate pulmonary ischaemia–reperfusion injury","abstract":"BACKGROUND: Pulmonary ischaemia-reperfusion injury (IRI) is a major contributor to poor lung transplant outcomes. We recently demonstrated a central role of airway-centred natural killer (NK) cells in mediating IRI; however, there are no existing effective therapies for directly targeting NK cells in humans. METHODS: (CD94) transcripts in bronchoalveolar lavage samples from lung transplant patients. RESULTS: We found that CD94 is highly expressed on mouse and human NK cells, with increased expression during IRI. Anti-mouse and anti-human mAbs against CD94 showed effective NK cell depletion in mouse and human models and blunted lung damage and airway epithelial killing, respectively. In two different allogeneic orthotopic lung transplant mouse models, anti-CD94 treatment during induction reduced early lung injury and chronic inflammation relative to control therapies. Anti-CD94 did not increase donor antigen-presenting cells that could alter long-term graft acceptance. CONCLUSIONS: Lung transplant induction regimens incorporating anti-CD94 treatment may safely improve early clinical outcomes.","journal":"European Respiratory Journal","year":2024,"id":458258,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9627,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342876,"name":"Longhui Qiu","orcid":"0000-0003-3122-9679","position":1,"is_corresponding":false},{"id":1284565,"name":"Reena Bharti","orcid":null,"position":2,"is_corresponding":false},{"id":618280,"name":"Avishai Shemesh","orcid":"0000-0002-6934-7155","position":3,"is_corresponding":false},{"id":1284566,"name":"Alberto M. 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Cleary","orcid":"0000-0001-5573-6363","position":5,"is_corresponding":false},{"id":336675,"name":"Nancy Greenland","orcid":"0000-0002-1783-1711","position":6,"is_corresponding":false},{"id":1068015,"name":"Jesse Santos","orcid":null,"position":7,"is_corresponding":false},{"id":1284125,"name":"Ruoshi Shi","orcid":"0000-0003-4146-519X","position":8,"is_corresponding":false},{"id":380245,"name":"Lu Bai","orcid":"0000-0002-2994-2064","position":9,"is_corresponding":false},{"id":1050736,"name":"Jennifer Richardson","orcid":"0000-0002-4137-3984","position":10,"is_corresponding":false},{"id":1284126,"name":"Kimberley Dilley","orcid":"0000-0002-3077-4889","position":11,"is_corresponding":false},{"id":1284567,"name":"Matthias Will","orcid":null,"position":12,"is_corresponding":false},{"id":1284568,"name":"Nenad Tomasevic","orcid":null,"position":13,"is_corresponding":false},{"id":1284569,"name":"Tereza Sputova","orcid":null,"position":14,"is_corresponding":false},{"id":1284570,"name":"Adam Salles","orcid":null,"position":15,"is_corresponding":false},{"id":425423,"name":"Jeffrey Kang","orcid":null,"position":16,"is_corresponding":false},{"id":1284127,"name":"Dongliang Zhang","orcid":"0009-0003-2500-1341","position":17,"is_corresponding":false},{"id":311017,"name":"Steven R. 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