{"doi":"10.1183/13993003.02146-2023","title":"Reply: Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease","abstract":"We thank J.A. Mackintosh and D.C. Chambers for their thoughtful discussions following our work detailing the pharmacogenetic interaction between telomere shortening and immunosuppression leading to harm in patients with non-idiopathic pulmonary fibrosis interstitial lung disease (ILD) patients [1]. Our findings suggest that shared genetic vulnerability to pulmonary fibrosis from telomere attrition may also inform a personalised approach to treatment. As J.A. Mackintosh and D.C. Chambers astutely point out, this study presumed an accurate ILD diagnostic categorisation through multidisciplinary discussions. Limitations notwithstanding, this classification schema remains the current standard for ILD diagnosis and treatment. While we agree with the prospect of genomics-informed ILD taxonomy as a successor to a purely phenotype-driven classification, we believe that the transition must be pursued carefully and systematically. As such, our findings of genomic marker associations with outcomes across ILD diagnostic subtypes is a rational next step towards incorporating genetic information into ILD decision-making. Refining ILD taxonomy through the lens of common molecular endotypes may inform personalised ILD management https://bit.ly/3RyRKrX","journal":"European Respiratory Journal","year":2024,"id":493409,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9588,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":285949,"name":"Ayodeji Adegunsoye","orcid":"0000-0002-7015-9610","position":1,"is_corresponding":false},{"id":285958,"name":"Justin M. Oldham","orcid":"0000-0003-4957-8869","position":2,"is_corresponding":false},{"id":3386,"name":"Paul J. Wolters","orcid":"0000-0002-3108-6164","position":3,"is_corresponding":false},{"id":314479,"name":"Christine Kim Garcia","orcid":"0000-0002-0771-1249","position":4,"is_corresponding":false},{"id":314478,"name":"Chad A. Newton","orcid":"0000-0001-5256-9029","position":5,"is_corresponding":false},{"id":621910,"name":"David Zhang","orcid":"0000-0002-2983-9796","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T02:09:03.883685Z","pmid":"38237997","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}