{"doi":"10.1183/13993003.02071-2023","title":"Airway-derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD","abstract":"Emphysema, the progressive destruction of gas exchange surfaces in the lungs, is a hallmark of COPD that is presently incurable. This therapeutic gap is largely due to a poor understanding of potential drivers of impaired tissue regeneration, such as abnormal lung epithelial progenitor cells, including alveolar type II (ATII) and airway club cells. We discovered an emphysema-specific subpopulation of ATII cells located in enlarged distal alveolar sacs, termed asATII cells. Single-cell RNA sequencing and in situ localisation revealed that asATII cells co-express the alveolar marker surfactant protein C and the club cell marker secretaglobin-3A2 (SCGB3A2). A similar ATII subpopulation derived from club cells was also identified in mouse COPD models using lineage labelling. Human and mouse ATII subpopulations formed 80–90% fewer alveolar organoids than healthy controls, indicating reduced progenitor function. Targeting asATII cells or their progenitor club cells could reveal novel COPD treatment strategies.","journal":"European Respiratory Journal","year":2024,"id":421996,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":12657,"name":"Qianjiang Hu","orcid":"0000-0003-1069-3181","position":1,"is_corresponding":false},{"id":537,"name":"Meshal Ansari","orcid":"0000-0002-8819-7965","position":2,"is_corresponding":false},{"id":225903,"name":"Kent Riemondy","orcid":"0000-0003-0750-1273","position":3,"is_corresponding":false},{"id":44869,"name":"Ricardo Pineda","orcid":"0000-0001-8768-4801","position":4,"is_corresponding":false},{"id":270566,"name":"John Sembrat","orcid":"0000-0003-4108-803X","position":5,"is_corresponding":false},{"id":1215001,"name":"Adriana S. Leme","orcid":"0000-0003-3608-5766","position":6,"is_corresponding":false},{"id":1215525,"name":"Kenny Ngo","orcid":null,"position":7,"is_corresponding":false},{"id":1215526,"name":"Olivia Morgenthaler","orcid":null,"position":8,"is_corresponding":false},{"id":1215527,"name":"Kellie Ha","orcid":null,"position":9,"is_corresponding":false},{"id":279693,"name":"Bifeng Gao","orcid":null,"position":10,"is_corresponding":false},{"id":44871,"name":"William J. Janssen","orcid":"0000-0002-6397-3454","position":11,"is_corresponding":false},{"id":228725,"name":"Maria C. Basil","orcid":"0000-0003-4716-1285","position":12,"is_corresponding":false},{"id":574590,"name":"Corrine R. Kliment","orcid":"0000-0002-3815-9370","position":13,"is_corresponding":false},{"id":228733,"name":"Edward E. Morrisey","orcid":"0000-0001-5785-1939","position":14,"is_corresponding":false},{"id":533,"name":"Mareike Lehmann","orcid":"0000-0002-8601-8206","position":15,"is_corresponding":false},{"id":302461,"name":"Christopher M. Evans","orcid":"0000-0001-5600-7314","position":16,"is_corresponding":false},{"id":573,"name":"Herbert B. Schiller","orcid":"0000-0001-9498-7034","position":17,"is_corresponding":false},{"id":574,"name":"Melanie Königshoff","orcid":"0000-0001-9414-5128","position":18,"is_corresponding":false},{"id":534,"name":"Yan Hu","orcid":"0000-0003-0586-6527","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T01:57:41.370244Z","pmid":"39147413","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}