{"doi":"10.1183/13993003.01410-2016","title":"Deterioration of pulmonary hypertension and pleural effusion with bosutinib following dasatinib lung toxicity","abstract":null,"journal":"European Respiratory Journal","year":2016,"id":604526,"datarank":2.686812928682852,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":2.0701818490568553,"self_endowment_contribution":0.6166310796259968,"citer_contribution":2.0701818490568553,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":41,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1551082,"name":"Andrei Seferian","orcid":null,"position":1,"is_corresponding":false},{"id":1219836,"name":"Laurent Savale","orcid":"0000-0002-6862-8975","position":2,"is_corresponding":false},{"id":1551083,"name":"Marie-Camille Chaumais","orcid":null,"position":3,"is_corresponding":false},{"id":621841,"name":"Christophe Guignabert","orcid":"0000-0002-8545-4452","position":4,"is_corresponding":false},{"id":1551084,"name":"Matthieu Canuet","orcid":null,"position":5,"is_corresponding":false},{"id":1551085,"name":"Pascal Magro","orcid":null,"position":6,"is_corresponding":false},{"id":1551086,"name":"Delphine Rea","orcid":null,"position":7,"is_corresponding":false},{"id":686248,"name":"Olivier Sitbon","orcid":"0000-0002-1942-1951","position":8,"is_corresponding":false},{"id":1551088,"name":"Xavier Jaïs","orcid":null,"position":9,"is_corresponding":false},{"id":57508,"name":"Marc Humbert","orcid":"0000-0003-0703-2892","position":10,"is_corresponding":false},{"id":161006,"name":"David Montani","orcid":null,"position":11,"is_corresponding":false},{"id":1551081,"name":"Marianne Riou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Deterioration of pulmonary hypertension and pleural effusion with bosutinib following dasatinib lung toxicity","abstract":"Tyrosine kinase inhibitors (TKIs) targeting BCR/ABL such as imatinib, nilotinib, dasatinib, bosutinib and ponatinib have revolutionised the management of patients with chronic myeloid leukaemia (CML) [1]. Pleural effusions and pulmonary arterial hypertension (PAH) have been reported in patients treated with these agents [2–4]. These side-effects are more frequently observed with dasatinib use, with partial or complete reversibility after drug withdrawal [3]. Bosutinib is a second-generation TKI prescribed in case of intolerance or resistance to imatinib, nilotinib or dasatinib. In the present report, we describe two cases of worsening of dasatinib-induced PAH and two cases of severe pleural effusions, suggesting overlapping pulmonary toxicity of bosutinib and dasatinib. Pulmonary complications of bosutinib therapy and potential cross-intolerance with dasatinib <http://ow.ly/UKWu303KGhx> We acknowledge the French pulmonary hypertension pharmacovigilance network, VIGIAPATH, supported by the Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM).","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27799395","pmcid":null,"openalex_id":"https://openalex.org/W2528230618","authors":[],"funders":[],"total_grants":0,"fwci":5.2128,"citation_percentile":0.96141827,"influential_citations":0,"citation_trend":[{"year":2017,"count":7},{"year":2018,"count":9},{"year":2019,"count":8},{"year":2020,"count":5},{"year":2021,"count":8},{"year":2022,"count":6},{"year":2023,"count":2},{"year":2024,"count":7},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://erj.ersjournals.com/content/erj/48/5/1517.full.pdf","host_type":"journal"},{"url":"https://erj.ersjournals.com/content/erj/48/5/1517.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1183/13993003.01410-2016","host_type":"publisher"},{"url":"https://doi.org/10.1183/13993003.01410-2016","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27799395","host_type":"repository"}],"fields_of_study":["Chronic Myeloid Leukemia Treatments","Eosinophilic Disorders and Syndromes","Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","Adult","Aged","Aged, 80 and over","Aniline Compounds","Dasatinib","Female","Humans","Hypertension, Pulmonary","Lung","Middle Aged","Nitriles","Pleural Effusion","Protein Kinase Inhibitors","Quinolines"],"mesh_terms":["Dasatinib","Adult","Aged","Aged, 80 and over","Aniline Compounds","Female","Humans","Hypertension, Pulmonary","Lung","Middle Aged","Nitriles","Pleural Effusion","Quinolines","Protein Kinase Inhibitors"],"keywords":["Bosutinib","Dasatinib","Nilotinib","Medicine","Imatinib","Ponatinib","Pulmonary toxicity","Tyrosine-kinase inhibitor","Pleural effusion","Internal medicine","Pulmonary hypertension","Pharmacology","Myeloid leukemia","Toxicity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:20:56.417998Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}