{"doi":"10.1182/blood.2020009779","title":"P-selectin deficiency promotes liver senescence in sickle cell disease mice","abstract":"Sickle cell disease (SCD) is caused by a homozygous mutation in the β-globin gene, which leads to erythrocyte sickling, vasoocclusion, and intense hemolysis. P-selectin inhibition has been shown to prevent vasoocclusive events in patients with SCD; however, the chronic effect of P-selectin inhibition in SCD remains to be determined. Here, we used quantitative liver intravital microscopy in our recently generated P-selectin-deficient SCD mice to show that chronic P-selectin deficiency attenuates liver ischemia but fails to prevent hepatobiliary injury. Remarkably, we find that this failure in resolution of hepatobiliary injury in P-selectin-deficient SCD mice is associated with the increase in cellular senescence and reduced epithelial cell proliferation in the liver. These findings highlight the importance of investigating the long-term effects of chronic P-selectin inhibition therapy on liver pathophysiology in patients with SCD.","journal":"Blood","year":2021,"id":174162,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":404874,"name":"Tomasz W. Kamiński","orcid":"0000-0002-8688-4171","position":1,"is_corresponding":false},{"id":713690,"name":"Eun-Mi Ju","orcid":null,"position":2,"is_corresponding":false},{"id":713691,"name":"Tomasz Brozska","orcid":null,"position":3,"is_corresponding":false},{"id":370289,"name":"Egemen Tütüncüoğlu","orcid":null,"position":4,"is_corresponding":false},{"id":347796,"name":"Jesús Tejero","orcid":"0000-0003-3245-9978","position":5,"is_corresponding":false},{"id":379109,"name":"Enrico M. Novelli","orcid":"0000-0003-3010-8285","position":6,"is_corresponding":false},{"id":369012,"name":"Prithu Sundd","orcid":"0000-0001-7568-5719","position":7,"is_corresponding":false},{"id":369013,"name":"Tirthadipa Pradhan‐Sundd","orcid":"0000-0002-8763-4844","position":8,"is_corresponding":false},{"id":369004,"name":"Ravi Vats","orcid":"0009-0009-9987-8828","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:54.772014Z","pmid":"33619560","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}